Mbd2 Gene Summary [Rat]
Predicted to enable several functions, including C2H2 zinc finger domain binding activity; RNA binding activity; and methyl-CpG binding activity. Involved in several processes, including cellular response to serotonin; maternal behavior; and regulation of gene expression. Located in chromatin. Used to study choline deficiency disease. Biomarker of choline deficiency disease and transient cerebral ischemia. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human MBD2 (methyl-CpG binding domain protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mbd2 |
| Official Name | methyl-CpG binding domain protein 2 [Source:RGD Symbol;Acc:1595452] |
| Ensembl ID | ENSRNOG00000011853 |
| Bio databases IDs | |
| Aliases | methyl-CpG binding domain protein 2 |
| Synonyms | DMTase, LOC684150, MBD2a, methyl-CpG binding domain protein 2, NY-CO-41 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mbd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- mRNA binding
- chromatin binding
- coiled-coil domain
- protein domain specific binding
- protein binding
- identical protein binding
- C-terminal domain of methyl-CpG binding protein 2 and 3
- DNA binding
- RNA binding
- Arg-Gly dipeptide repeat domain
- satellite DNA binding
- methyl-CpG binding
- p55-binding region of Methyl-CpG-binding domain proteins MBD
- glycine arginine rich domain
- MBD
Pathways
Biological processes and signaling networks where the Mbd2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- glioblastoma
- COVID-19
- metastasis
- chronic kidney disease
- glioblastoma cancer
- systemic juvenile idiopathic arthritis
role in cell
- expression in
- proliferation
- differentiation
- invasion
- remodeling
- migration
- growth
- invasion by
- silencing in
- methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mbd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- embryonic organ development
- regulation of cell proliferation
- maternal behavior
- response to mechanical stimulus
- methylation-dependent chromatin silencing
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- ventricular cardiac muscle tissue development
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- response to estradiol stimulus
- Wnt receptor signaling pathway
- positive regulation of Wnt receptor signaling pathway
- cellular response to organic cyclic compound
- response to nutrient levels
Cellular Component
Where in the cell the gene product is active
- heterochromatin
- nucleus
- NuRD complex
- cytosol
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein domain specific binding
- protein binding
- siRNA binding
- nucleosomal DNA binding
- C2H2 zinc finger domain binding
- mRNA binding
- methyl-CpG binding
- satellite DNA binding
- binding, bridging