Erg Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Biomarker of pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in hereditary lymphedema and myeloid leukemia. Orthologous to human ERG (ETS transcription factor ERG). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Erg |
| Official Name | ETS transcription factor ERG [Source:RGD Symbol;Acc:621108] |
| Ensembl ID | ENSRNOG00000001652 |
| Bio databases IDs | |
| Aliases | ETS transcription factor ERG |
| Synonyms | D030036I24Rik, ETS2 RELATED, ETS transcription factor, ETS transcription factor ERG, LMPHM14, p55, Vascular endothelial cell-specific protein 14, Vesp14 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Erg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- DNA binding domain
- nucleic acid binding
- SAM (Sterile alpha motif )
- transcription activation domain
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Sterile alpha motif (SAM)/Pointed domain
- N-terminal transactivation domain
- double-stranded DNA binding
- Ets-domain
- pointed domain
- CAD domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- COVID-19
- precursor B-cell acute lymphoblastic leukemia
- cancer
- epithelial cancer
- multiple sclerosis
- Dupuytren contracture
- type M7 acute myeloid leukemia
- prostate cancer
- thrombocytopenia
role in cell
- production in
- expression in
- proliferation
- phosphorylation in
- activation in
- apoptosis
- quantity
- growth
- formation in
- senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cell surface
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Erg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- cell differentiation
- protein phosphorylation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity