Gdpd2 Gene Summary [Rat]
Predicted to enable glycerophosphodiester phosphodiesterase activity. Predicted to be involved in lipid metabolic process. Predicted to act upstream of or within actin filament organization and positive regulation of osteoblast differentiation. Predicted to be located in actin filament and lamellipodium. Predicted to be active in plasma membrane. Orthologous to human GDPD2 (glycerophosphodiester phosphodiesterase domain containing 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gdpd2 |
| Official Name | glycerophosphodiester phosphodiesterase domain containing 2 [Source:RGD Symbol;Acc:1560780] |
| Ensembl ID | ENSRNOG00000002800 |
| Bio databases IDs | |
| Aliases | glycerophosphodiester phosphodiesterase domain containing 2 |
| Synonyms | 9130017L10Rik, GDE3, glycerophosphodiester phosphodiesterase 3, glycerophosphodiester phosphodiesterase domain containing 2, OBDPF, RGD1560780 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gdpd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycerophosphoryl diester phosphodiesterase family
- enzyme
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- Ca2+
- 18:1 lysophosphatidylinositol
- 18:0 lysophosphatidylinositol
- 2-arachidonoylglycerol
- 1-16:0 lysophosphatidylinositol
- 20:4 lysophosphatidylinositol
regulated by
- MET
- capmatinib
disease
- habitual abortion
- diabetic nephropathy
role in cell
- differentiation
- quantity
- cell cycle progression
- cell rounding
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell periphery
- actin cytoskeleton
- actin filaments
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gdpd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid metabolic process
- actin filament organization
- positive regulation of osteoblast differentiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- actin filament
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- glycerophosphoinositol inositolphosphodiesterase activity
- metal ion binding
- glycerophosphodiester phosphodiesterase activity