Gdpd2 Gene Summary [Mouse]
This gene encodes a member of the glycerophosphodiester phosphodiesterase enzyme family. The encoded protein hydrolyzes glycerophosphoinositol to produce inositol 1-phosphate and glycerol. Overexpression of this gene is associated with activity-dependent actin cytoskeleton disorganization. The encoded protein may negatively regulate growth rate and induce differentiation of osteoblasts. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Details
| Type | Processed Transcript |
| Official Symbol | Gdpd2 |
| Official Name | glycerophosphodiester phosphodiesterase domain containing 2 [Source:MGI Symbol;Acc:MGI:1918834] |
| Ensembl ID | ENSMUSG00000019359 |
| Bio databases IDs | |
| Aliases | glycerophosphodiester phosphodiesterase domain containing 2 |
| Synonyms | 9130017L10Rik, GDE3, glycerophosphodiester phosphodiesterase 3, glycerophosphodiester phosphodiesterase domain containing 2, OBDPF, RGD1560780 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gdpd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycerophosphoryl diester phosphodiesterase family
- enzyme
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- habitual abortion
- diabetic nephropathy
regulated by
- MET
- capmatinib
regulates
- Ca2+
- 18:1 lysophosphatidylinositol
- 18:0 lysophosphatidylinositol
- 2-arachidonoylglycerol
- 1-16:0 lysophosphatidylinositol
- 20:4 lysophosphatidylinositol
role in cell
- differentiation
- quantity
- cell cycle progression
- cell rounding
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell periphery
- actin cytoskeleton
- actin filaments
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gdpd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid metabolic process
- actin filament organization
- positive regulation of osteoblast differentiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- actin filament
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- glycerophosphoinositol inositolphosphodiesterase activity
- metal ion binding
- glycerophosphodiester phosphodiesterase activity