Afp Gene Summary [Rat]
Predicted to enable metal ion binding activity. Involved in several processes, including cellular response to retinoic acid; liver regeneration; and response to tetrachloromethane. Located in extracellular space. Biomarker of hepatitis and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human AFP (alpha fetoprotein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Afp |
| Official Name | alpha-fetoprotein [Source:RGD Symbol;Acc:2065] |
| Ensembl ID | ENSRNOG00000002889 |
| Bio databases IDs | |
| Aliases | alpha-fetoprotein |
| Synonyms | alpha-fetoprotein, α-1-fetoprotein, α-fetoprotein |
| Species | Rat, Rattus norvegicus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Afp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ALBUMIN
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm