Nkx2-8 Gene Summary [Rat]
Enables sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; positive regulation of transcription by RNA polymerase II; and transcription by RNA polymerase II. Predicted to act upstream of or within axonogenesis; lung development; and negative regulation of epithelial cell proliferation. Predicted to be active in nucleus. Orthologous to human NKX2-8 (NK2 homeobox 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nkx2-8 |
| Official Name | NK2 homeobox 8 [Source:RGD Symbol;Acc:1310629] |
| Ensembl ID | ENSRNOG00000022970 |
| Bio databases IDs | |
| Aliases | NK2 homeobox 8 |
| Synonyms | NK2 homeobox 8, NK2 homeobox 9, NKX2.8, Nkx-2.9, Nkx2-9, NKX2H, tinman |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nkx2-8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
- TN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pancreatic cancer
- ductal breast carcinoma
- ductal breast cancer
- hyperplasia
- EGFR mutation positive adenocarcinoma of the lung
- EGFR mutation positive non-small cell lung cancer
- lung adenocarcinoma formation
- EGFR expression positive non-squamous non-small cell lung cancer
role in cell
- quantity
- proliferation
- growth
- development
- tumorigenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nkx2-8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell proliferation
- transcription, DNA-dependent
- axonogenesis
- liver development
- negative regulation of epithelial cell proliferation
- cell differentiation
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- lung development
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- double-stranded DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity