Cxcl12 Gene Summary [Rat]
Predicted to enable CXCR chemokine receptor binding activity; chemokine activity; and integrin binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; nervous system development; and positive regulation of cell differentiation. Located in extracellular space. Used to study myocardial infarction. Biomarker of anti-basement membrane glomerulonephritis; brain ischemia (multiple); myocardial infarction; status epilepticus; and traumatic brain injury. Human ortholog(s) of this gene implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Orthologous to human CXCL12 (C-X-C motif chemokine ligand 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cxcl12 |
| Official Name | C-X-C motif chemokine ligand 12 [Source:RGD Symbol;Acc:3651] |
| Ensembl ID | ENSRNOG00000013589 |
| Bio databases IDs | |
| Aliases | C-X-C motif chemokine ligand 12 |
| Synonyms | CXCL12 isoform 1, C-X-C motif chemokine ligand 12, hIRH, IRH, LOC105378278, PBSF, SCYB12, SDF, SDF1, SDF-1a, SDF-1alpha, SDF-1α, Stromal cell derived factor 1, TLSF, TPAR1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cxcl12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- chemokine receptor binding
- integrin binding
- heparin binding domain
- protein binding
- receptor binding
- cytokine
- N-terminal methionine
- CXCR chemokine receptor binding
Pathways
Biological processes and signaling networks where the Cxcl12 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Atherosclerosis Signaling
- Axonal Guidance Signaling
- Chemokine Signaling
- CXCR4 Signaling
- Ephrin B Signaling
- Ephrin Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- IL-17A Signaling in Fibroblasts
- Leukocyte Extravasation Signaling
- Neuroinflammation Signaling Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hemangioma
- hepatocellular carcinoma
- immunodeficiency
- oral squamous cell carcinoma
- plasma cell myeloma
- non-Hodgkin disease
- gastric cancer
- bladder cancer
- endometrial cancer
regulated by
- genistein
- 4-phenylbutyric acid
- ciprofibrate
- homocysteine
- beta-estradiol
- methotrexate
- RIGI
- BILF1
- blood platelets
- VHL
role in cell
- growth
- apoptosis
- cell death
- expression in
- accumulation in
- quantity
- number
- invasion
- production in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- inner surface
- Cytoplasm
- cell surface
- intracellular space
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- basolateral cell surfaces
- plasma membrane extracellular face
- nuclear scaffolds
- alpha granules
- neurites
- extracellular matrix
- membrane rafts
- axons
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cxcl12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin polymerization or depolymerization
- positive regulation of neuron differentiation
- telencephalon cell migration
- axon guidance
- adult locomotory behavior
- cell adhesion
- positive regulation of cell adhesion
- response to virus
- cell chemotaxis
- chemotaxis
- neuron migration
- response to hypoxia
- immune response
- induction of positive chemotaxis
- chemokine (C-X-C motif) ligand 12 signaling pathway
- G-protein coupled receptor signaling pathway
- positive regulation of monocyte chemotaxis
- signal transduction
- CXCL12-activated CXCR4 signaling pathway
- blood circulation
- positive regulation of axon extension involved in axon guidance
- defense response
- response to peptide hormone stimulus
- cellular calcium ion homeostasis
- positive regulation of calcium ion import
- positive regulation of T cell migration
- negative regulation of dendritic cell apoptotic process
- chemokine-mediated signaling pathway
- detection of mechanical stimulus involved in sensory perception of pain
- organ regeneration
- positive regulation of endothelial cell proliferation
- positive regulation of dopamine secretion
- detection of temperature stimulus involved in sensory perception of pain
- integrin activation
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- external side of plasma membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- CXCR chemokine receptor binding
- integrin binding
- chemokine activity
- receptor binding
- chemokine receptor binding