Ccdc103 Gene Summary [Rat]
Predicted to enable protein homodimerization activity. Predicted to be involved in axonemal dynein complex assembly; determination of left/right symmetry; and epithelial cilium movement involved in extracellular fluid movement. Predicted to be located in extracellular region and motile cilium. Predicted to be part of outer dynein arm. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 17. Orthologous to human DNAAF19 (dynein axonemal assembly factor 19). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccdc103 |
| Official Name | coiled-coil domain containing 103 [Source:RGD Symbol;Acc:1562370] |
| Ensembl ID | ENSRNOG00000002905 |
| Bio databases IDs | |
| Aliases | coiled-coil domain containing 103 |
| Synonyms | 1700039D13RIK, 4933439F11Rik, CCDC103, CILD17, coiled-coil domain containing 103, dynein axonemal assembly factor 19, LOC100042500, LOC100045630, PR46b, RGD1562370, Riken cDNA 1700039d13, SMH |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccdc103 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein homodimerization
- coiled-coil domain
- protein binding
- Potential Monad-binding region of RPAP3
- Dynein attachment factor N-terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- axonemes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccdc103 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cilium movement involved in determination of left/right asymmetry
- outer dynein arm assembly
- determination of digestive tract left/right asymmetry
- axonemal dynein complex assembly
- heart looping
- epithelial cilium movement
- cilium movement
- inner dynein arm assembly
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- motile cilium
- outer dynein arm
- cytoplasm
- extracellular region
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding