Suox Gene Summary [Rat]
Enables heme binding activity; molybdopterin cofactor binding activity; and sulfite oxidase activity. Involved in response to nutrient. Predicted to be located in mitochondrial intermembrane space. Predicted to be active in mitochondrion. Biomarker of steatotic liver disease. Human ortholog(s) of this gene implicated in inherited metabolic disorder and isolated sulfite oxidase deficiency. Orthologous to human SUOX (sulfite oxidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Suox |
| Official Name | sulfite oxidase [Source:RGD Symbol;Acc:619994] |
| Ensembl ID | ENSRNOG00000005987 |
| Bio databases IDs | |
| Aliases | sulfite oxidase |
| Synonyms | SO, Sulfite oxidase, sulphite oxidase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Suox often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sulfite oxidase
- binding protein
- SO_family_Moco
- Oxidoreductase molybdopterin binding domain
- Cytochrome b5-like Heme/Steroid binding domain
- enzyme
- protein binding
- heme binding
- Mo-co oxidoreductase dimerization domain
Pathways
Biological processes and signaling networks where the Suox gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sulfite oxidase deficiency
- sulfocysteinuria
- hereditary disorder
- asthma
- respiratory disorder
- rheumatoid arthritis
regulates
- sulfurous acid
role in cell
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial intermembrane space
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Suox gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sulfur compound metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding
- sulfite oxidase activity
- molybdenum ion binding
- heme binding
- molybdopterin cofactor binding