Atp2b4 Gene Summary [Rat]
Enables P-type calcium transporter activity; PDZ domain binding activity; and protein kinase binding activity. Involved in several processes, including calcium ion transport; hippocampus development; and negative regulation of calcineurin-NFAT signaling cascade. Located in basolateral plasma membrane and sperm principal piece. Is active in glutamatergic synapse and presynaptic active zone membrane. Biomarker of dystonia. Orthologous to human ATP2B4 (ATPase plasma membrane Ca2+ transporting 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp2b4 |
| Official Name | ATPase plasma membrane Ca2+ transporting 4 [Source:RGD Symbol;Acc:621305] |
| Ensembl ID | ENSRNOG00000003031 |
| Bio databases IDs | |
| Aliases | ATPase plasma membrane Ca2+ transporting 4 |
| Synonyms | ATP2B2, ATPase, Ca++ transporting, plasma membrane 4, ATPase plasma membrane Ca2+ transporting 4, LOC108352534, MXRA1, PMCA4, Pmca4b |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp2b4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cation transporter/ATPase, N-terminus
- sarco/endoplasmic reticulum calcium-translocating P-type ATPase
- enzyme inhibitor activity
- heavy metal translocating P-type ATPase
- E1-E2 ATPase
- copper-(or silver)-translocating P-type ATPase
- plasma-membrane calcium-translocating P-type ATPase
- nitric oxide synthase regulator
- phospholipid-translocating P-type ATPase, flippase
- Na,H/K antiporter P-type ATPase alpha subunit
- potassium and/or sodium efflux P-type ATPase, fungal-type
- Cation transport ATPase (P-type)
- Cation transporting ATPase, C-terminus
- autoinhibitory protein domain
- Ca2+-transporting ATPase
- protein kinase binding
- calcium ion transporter
- calmodulin binding
- heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase
- catalytic domain
- enzyme binding
- sodium channel regulator
- protein binding
- P-type ATPase of unknown pump specificity (type V)
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- Plasma membrane calcium transporter ATPase C terminal
- PDZ-domain binding
- protein phosphatase 2B binding
- K+-transporting ATPase, B subunit
- PDZ binding motif
- Haloacid Dehalogenase-like Hydrolases
- transporter
Pathways
Biological processes and signaling networks where the Atp2b4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic scoliosis
- diabetic nephropathy
- falciparum malaria
- Hutchinson-Gilford progeria syndrome
- asthenozoospermia
- spontaneous hypertension
- idiopathic pulmonary fibrosis
- malaria
role in cell
- expression in
- apoptosis
- development
- migration
- cell death
- function
- response by
- phosphorylation in
- inhibition in
- afterhyperpolarization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- cilia
- cellular membrane
- Nucleus
- basal bodies
- Mitochondria
- microsome
- presynaptic membrane
- caveolae
- basolateral membrane
- sperm tail
- acrosome
- sperm head
- synaptic vesicles
- axonal membrane
- sarcolemma
- Z line
- transverse tubules
- membrane rafts
- axons
- axon branches
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp2b4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- negative regulation of blood vessel endothelial cell migration
- negative regulation of arginine catabolic process
- spermatogenesis
- ion transmembrane transport
- cytosolic calcium ion homeostasis
- hippocampus development
- nitric oxide-cGMP-mediated signaling pathway
- negative regulation of nitric oxide biosynthetic process
- regulation of transcription from RNA polymerase II promoter
- cellular calcium ion homeostasis
- response to hydrostatic pressure
- negative regulation of gene expression
- sperm motility
- negative regulation of nitric-oxide synthase activity
- cellular response to epinephrine stimulus
- neural retina development
- negative regulation of calcineurin-NFAT signaling cascade
- calcium ion transmembrane transport
- urinary bladder smooth muscle contraction
- negative regulation of adrenergic receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- presynaptic active zone membrane
- plasma membrane
- Z disc
- T-tubule
- caveola
- intracellular membrane-bounded organelle
- membrane raft
- membrane
- sperm principal piece
- macromolecular complex
- sperm flagellum
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- protein kinase binding
- calcium ion transmembrane transporter activity
- calcium-transporting ATPase activity
- sodium channel regulator activity
- ATP binding
- scaffold protein binding
- calmodulin binding
- protein binding
- metal ion binding
- PDZ domain binding
- nitric-oxide synthase binding
- protein phosphatase 2B binding