Calm2 Gene Summary [Rat]
Enables several functions, including nitric-oxide synthase binding activity; nitric-oxide synthase regulator activity; and transmembrane transporter binding activity. Involved in several processes, including positive regulation of nitric-oxide synthase activity; regulation of calcium ion transmembrane transporter activity; and regulation of vesicle-mediated transport. Located in several cellular components, including growth cone; myelin sheath; and synaptic vesicle membrane. Is active in Schaffer collateral - CA1 synapse; postsynaptic cytosol; and presynaptic cytosol. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy and long QT syndrome 16. Orthologous to human CALM3 (calmodulin 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Calm2 |
| Official Name | calmodulin 2 [Source:RGD Symbol;Acc:2258] |
| Ensembl ID | ENSRNOG00000016770 |
| Bio databases IDs | |
| Aliases | calmodulin 2 |
| Synonyms | CALM, calmodulin 3, Calmodulin-R3, CaM, CAM1, CAM2, Cam3, CaMA, CAMB, Camc, CaMIII, CAM KINASE3, CPVT6, HEL-S-72, LOC100503341, LQT16, PHKD, PHKD3, RNCAMIII |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Calm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein-coupled receptor binding
- protein phosphatase regulator
- Ca2+ insensitive EF hand
- EFh_MICU
- enzyme activator activity
- EFh_PI-PLC
- EF-hand domain
- cytoskeletal protein binding
- nitric oxide synthase regulator
- EF hand
- ion channel binding
- calcium-dependent protein binding
- EF-hand, calcium binding motif
- calcium channel inhibitor
- protein kinase binding
- EF-hand domain pair
- enzyme binding
- calcium ion binding
- EFh
- protein domain specific binding
- enzyme regulator activity
- protein binding
- receptor binding
- calcium channel regulator
- protein kinase activator
- phosphoinositide 3-kinase binding
- adenylate cyclase binding
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- phosphatase activator
Pathways
Biological processes and signaling networks where the Calm2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- long QT syndrome type 16
- long QT syndrome 1
- aortic valve calcification
- gastric adenocarcinoma
- long-QT syndrome
- gastric epithelial cancer
- severe acute respiratory syndrome
- catecholaminergic polymorphic ventricular tachycardia
role in cell
- growth
- expression in
- activation in
- survival
- G2/M phase transition
- signaling in
- cytokinesis in
- exocytosis
- endocytosis
- action potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- Nucleus
- Plasma Membrane
- centrosome
- sarcomere
- cytosol
- mitochondrial membrane
- nucleoplasm
- spindle pole
- spindle fibers
- growth cone
- myelin sheath
- synapse
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Calm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- G-protein coupled receptor signaling pathway
- positive regulation of ryanodine-sensitive calcium-release channel activity
- substantia nigra development
- negative regulation of ryanodine-sensitive calcium-release channel activity
- detection of calcium ion
- regulation of heart rate
- positive regulation of protein autophosphorylation
- positive regulation of cyclic-nucleotide phosphodiesterase activity
- positive regulation of phosphoprotein phosphatase activity
- G2/M transition of mitotic cell cycle
- negative regulation of peptidyl-threonine phosphorylation
- response to calcium ion
- regulation of cytokinesis
- regulation of calcium-mediated signaling
- positive regulation of peptidyl-threonine phosphorylation
- positive regulation of protein dephosphorylation
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- positive regulation of protein serine/threonine kinase activity
- regulation of cardiac muscle contraction
Cellular Component
Where in the cell the gene product is active
- myelin sheath
- voltage-gated potassium channel complex
- spindle pole
- plasma membrane
- spindle microtubule
- nucleus
- centrosome
- calcium channel complex
- sperm midpiece
- cytoplasm
- vesicle
- macromolecular complex
- sarcomere
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- protein serine/threonine kinase activator activity
- protein phosphatase activator activity
- adenylate cyclase activator activity
- calcium ion binding
- calcium-dependent protein binding
- titin binding
- adenylate cyclase binding
- ion channel binding