Mip Gene Summary [Rat]
Enables water channel activity. Involved in canalicular bile acid transport and water transport. Located in intracellular canaliculus. Human ortholog(s) of this gene implicated in cataract and cataract 15 multiple types. Orthologous to human MIP (major intrinsic protein of lens fiber). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mip |
| Official Name | major intrinsic protein of lens fiber [Source:RGD Symbol;Acc:3090] |
| Ensembl ID | ENSRNOG00000003132 |
| Bio databases IDs | |
| Aliases | major intrinsic protein of lens fiber |
| Synonyms | AQP0, Cat, CTRCT15, Cts, Hfi, LIM1, Lop, major intrinsic protein of lens fiber, MIP26, MP26, shrivelled, Svl |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of eye lens
- calmodulin binding
- MIP
- cell adhesion molecule binding
- protein binding
- water channel
- transporter
Pathways
Biological processes and signaling networks where the Mip gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- water
- bile acid
disease
- non-insulin-dependent diabetes mellitus
- lamellar with sutural opacities cataract 15
- hereditary disorder
- persistent hyperplastic primary vitreous
- congenital cataract
- multiple types cataract 15
role in cell
- architecture
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- insoluble fractions
- intracellular space
- intracellular membranes
- cellular membrane
- vesicles
- Endoplasmic Reticulum
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- water transport
- protein homotetramerization
- transmembrane transport
- positive regulation of cell adhesion
- lens development in camera-type eye
- visual perception
Cellular Component
Where in the cell the gene product is active
- gap junction
- endoplasmic reticulum
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- water channel activity
- structural constituent of eye lens