Aqp9 Gene Summary [Rat]
Enables channel activity and nucleobase transmembrane transporter activity. Involved in several processes, including canalicular bile acid transport; nucleobase transport; and response to pain. Located in basolateral plasma membrane. Orthologous to human AQP9 (aquaporin 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aqp9 |
| Official Name | aquaporin 9 [Source:RGD Symbol;Acc:68433] |
| Ensembl ID | ENSRNOG00000061883 |
| Bio databases IDs | |
| Aliases | aquaporin 9 |
| Synonyms | 1700020I22RIK, aquaporin 9, HsT17287, SSC1, T17287 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aqp9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- purine transporter
- channel/pore class transporter
- MIP
- glycerol channel
- urea transporter
- inorganic uptake permease
- protein binding
- polyol transporter
- pyrimidine transporter
- water channel
- transporter
- urea channel
Pathways
Biological processes and signaling networks where the Aqp9 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- psoriasis
- osteoarthritis
- coronary artery disease
- primary pulmonary hypertension
- rheumatoid arthritis
- colorectal cancer
- ulcerative colitis
- liver cancer
- hepatitis B virus-related hepatocellular carcinoma
role in cell
- chemotaxis
- production in
- growth
- function
- motility
- urea permeability
- glycerol permeability
- roundness
- polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- intracellular membrane-bounded organelle
- cell borders
- cellular membrane
- basolateral cell surfaces
- basolateral membrane
- sinusoidal membrane
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aqp9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to pain
- water transport
- glycerol transport
- pyrimidine-containing compound transmembrane transport
- urea transmembrane transport
- cellular response to cAMP
- amine transport
- pyrimidine base transport
- canalicular bile acid transport
- purine base transport
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- glycerol channel activity
- urea channel activity
- pyrimidine base transmembrane transporter activity
- water channel activity
- purine base transmembrane transporter activity
- urea transmembrane transporter activity