Mip Gene Summary [Mouse]
Enables water channel activity. A structural constituent of eye lens. Acts upstream of or within lens development in camera-type eye; visual perception; and water transport. Located in plasma membrane. Is expressed in several structures, including eye; femur; and main olfactory bulb. Used to study cataract 15 multiple types. Human ortholog(s) of this gene implicated in cataract and cataract 15 multiple types. Orthologous to human MIP (major intrinsic protein of lens fiber). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mip |
| Official Name | major intrinsic protein of lens fiber [Source:MGI Symbol;Acc:MGI:96990] |
| Ensembl ID | ENSMUSG00000025389 |
| Bio databases IDs | |
| Aliases | major intrinsic protein of lens fiber |
| Synonyms | AQP0, Cat, CTRCT15, Cts, Hfi, LIM1, Lop, major intrinsic protein of lens fiber, MIP26, MP26, shrivelled, Svl |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of eye lens
- calmodulin binding
- MIP
- cell adhesion molecule binding
- protein binding
- water channel
- transporter
Pathways
Biological processes and signaling networks where the Mip gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- lamellar with sutural opacities cataract 15
- hereditary disorder
- persistent hyperplastic primary vitreous
- congenital cataract
- multiple types cataract 15
regulates
- water
- bile acid
role in cell
- architecture
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- insoluble fractions
- intracellular space
- intracellular membranes
- cellular membrane
- vesicles
- Endoplasmic Reticulum
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- water transport
- protein homotetramerization
- transmembrane transport
- positive regulation of cell adhesion
- lens development in camera-type eye
- visual perception
Cellular Component
Where in the cell the gene product is active
- gap junction
- endoplasmic reticulum
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- water channel activity
- structural constituent of eye lens