Wdr81 Gene Summary [Rat]
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and phosphatidylinositol 3-kinase inhibitor activity. Predicted to be involved in several processes, including aggrephagy; early endosome to late endosome transport; and protein stabilization. Predicted to be located in bounding membrane of organelle and cytosol. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 2 and hydrocephalus. Orthologous to human WDR81 (WD repeat domain 81). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdr81 |
| Official Name | WD repeat domain 81 [Source:RGD Symbol;Acc:1311334] |
| Ensembl ID | ENSRNOG00000003243 |
| Bio databases IDs | |
| Aliases | WD repeat domain 81 |
| Synonyms | CAMRQ2, CHMRQ, Gm883, HYC3, mFLJ00182, nur5, PPP1R166, RGD1311334, SORF-2, WD repeat domain 81 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wdr81 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- phosphoinositide 3-kinase regulator
- protein binding
- Beach
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cerebellar ataxia, mental retardation, and dysequilibrium syndrome type 2
- cerebellar ataxia
- congenital hydrocephalus with brain anomalies type 3
- Alzheimer disease
- hereditary disorder
- gait disturbance
- gout
- microcephaly with microlissencephaly
regulated by
- A549 cells
regulates
role in cell
- loss
- accumulation in
- organization
- accumulation
- degeneration
- structural alteration in
- structural alteration
- interaction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Mitochondria
- cytosol
- lysosome membrane
- endosomal membrane
- photoreceptor inner segments
- autophagic vacuoles
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wdr81 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- early endosome to late endosome transport
- protein stabilization
- aggrephagy
- mitochondrion organization
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- endoplasmic reticulum membrane
- late endosome membrane
- mitochondrion
- cytosol
- Golgi apparatus
- endosome membrane
- lysosomal membrane
- autophagic vacuole membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol 3-kinase regulator activity
- protein binding
- K63-linked polyubiquitin binding