Cenpf Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor binding activity; dynein complex binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including metaphase chromosome alignment; regulation of G2/M transition of mitotic cell cycle; and ventricular system development. Predicted to act upstream of or within regulation of striated muscle tissue development. Predicted to be located in several cellular components, including cytoskeleton; midbody; and nucleus. Predicted to be part of ciliary transition fiber and outer kinetochore. Predicted to be active in chromosome, centromeric region; nucleus; and spindle pole. Human ortholog(s) of this gene implicated in Stromme syndrome. Orthologous to human CENPF (centromere protein F). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cenpf |
| Official Name | centromere protein F [Source:RGD Symbol;Acc:628667] |
| Ensembl ID | ENSRNOG00000003388 |
| Bio databases IDs | |
| Aliases | centromere protein F |
| Synonyms | 6530404A22Rik, CENF, centromere protein F, CILD31, hcp-1, LEK1, MITOSIN, PRO1779, STROMS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cenpf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- pRb binding domain
- chromosome segregation protein SMC, primarily archaeal type
- Rb-binding domain of kinetochore protein Cenp-F/LEK1
- exonuclease SbcC
- Cenp-F N-terminal domain
- rad50
- Synaptonemal complex protein 1 (SCP-1)
- Myosin tail
- transcription factor binding
- helix-rich Mycoplasma protein
- leucine zipper domain
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Alpha helical coiled-coil rod protein (HCR)
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- RIM-binding protein of the cytomatrix active zone
- binding protein
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- protein homodimerization
- Intermediate filament protein
- HOOK protein coiled-coil region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell lung cancer
- epithelial cancer
- liver cancer
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- organismal death
- rectal adenocarcinoma
- colorectal carcinomagenesis
- rectum cancer
- hepatocellular carcinoma
regulates
- E2F1
- CHEK1
- RB
- CENPE
role in cell
- expression in
- activation in
- apoptosis
- formation in
- proliferation
- binding in
- migration
- organization
- formation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- ciliary transition fiber
- Cytoplasm
- perinuclear region
- basal bodies
- centrosome
- axonemes
- midbody
- cytosol
- nucleoplasm
- spindle pole
- nuclear envelope
- nuclear matrix
- pronucleus
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cenpf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- protein transport
- chromosome segregation
- kinetochore assembly
- response to xenobiotic stimulus
- mitotic cell cycle
- cell division
- muscle organ development
- ventricular system development
- metaphase plate congression
- negative regulation of transcription, DNA-dependent
- kidney development
- cell differentiation
- DNA biosynthetic process
- regulation of striated muscle tissue development
- regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- cilium basal body
- spindle pole
- kinetochore
- condensed chromosome outer kinetochore
- chromosome, centromeric region
- chromatin
- axoneme
- nucleoplasm
- nuclear envelope
- nucleus
- nuclear membrane
- centrosome
- perinuclear region of cytoplasm
- cytoplasm
- pronucleus
- spindle
- nuclear matrix
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- dynein complex binding
- chromatin binding
- microtubule binding