Hsp90ab1 Gene Summary [Rat]
Enables several functions, including nucleotide binding activity; sulfonylurea receptor binding activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of complement-dependent cytotoxicity; positive regulation of cell size; and regulation of protein metabolic process. Located in several cellular components, including basolateral plasma membrane; brush border membrane; and sperm head plasma membrane. Part of protein folding chaperone complex. Biomarker of muscular atrophy; pancreatitis; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to several human genes including HSP90AB1 (heat shock protein 90 alpha family class B member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hsp90ab1 |
| Official Name | heat shock protein 90 alpha family class B member 1 [Source:RGD Symbol;Acc:1303075] |
| Ensembl ID | ENSRNOG00000019834 |
| Bio databases IDs | |
| Aliases | heat shock protein 90 alpha family class B member 1 |
| Synonyms | C81438, D6S182, heat shock protein 90 alpha (cytosolic), class B member 1, heat shock protein 90 alpha family class B member 1, heat shock protein 90 α (cytosolic), class B member 1, heat shock protein 90 α family class B member 1, Hsp1beta, HSP84, Hsp84-1, Hsp90, Hsp90ab, HSP90B, HSP90-BETA, Hsp90 α, HSP90-β, HSPC2, HSPCB, LOC100505819 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hsp90ab1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- peptide binding
- Histidine kinase-like ATPase domain
- ATP-binding domain
- ATP binding
- heat shock protein binding
- protein phosphatase regulator
- protein kinase regulator
- enzyme
- pyrimidine nucleotide binding
- identical protein binding
- ATPase
- purine nucleotide binding
- Hsp90 protein
- nitric oxide synthase regulator
- tau protein binding
- PRK05218
- double-stranded RNA binding
- ATP-dependent protein binding
- ion channel binding
- ubiquitin protein ligase binding
- nucleotide binding
- dimerization domain
- protein kinase binding
- enzyme binding
- central domain
- histone deacetylase binding
- protein domain specific binding
- protein binding
- sulfonylurea receptor binding
- GTP binding
- Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
- binding protein
- kinase binding
- adenyl nucleotide binding
- protein homodimerization
- phosphatase activator
- Histidine kinase-like ATPases
Pathways
Biological processes and signaling networks where the Hsp90ab1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Aldosterone Signaling in Epithelial Cells
- Aryl Hydrocarbon Receptor Signaling
- Cellular Effects of Sildenafil (Viagra)
- Chronic Myeloid Leukemia Signaling
- eNOS Signaling
- Glucocorticoid Receptor Signaling
- Human Embryonic Stem Cell Pluripotency
- Hypoxia Signaling in the Cardiovascular System
- IL-17 Signaling
- Mitotic Roles of Polo-Like Kinase
- Neuregulin Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- NRF2-mediated Oxidative Stress Response
- PPAR Signaling
- PPARα/RXRα Activation
- Prostate Cancer Signaling
- Protein Ubiquitination Pathway
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of PKR in Interferon Induction and Antiviral Response
- Telomerase Signaling
- Th17 Activation Pathway
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- metastatic breast cancer
- advanced breast cancer
- invasive breast cancer
- metastatic invasive breast cancer
- locally advanced breast cancer
- plasma cell myeloma
- breast cancer
- metastatic melanoma
- locally advanced gastric adenocarcinoma
role in cell
- expression in
- migration
- proliferation
- invasion by
- growth
- cell viability
- cell death
- apoptosis
- binding in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- membrane fraction
- detergent resistant lipid raft fraction
- axon component
- extracellular vesicles
- secretory granule lumen
- ficolin-1-rich granule lumen
- organelle
- cell surface
- Extracellular Space
- intracellular space
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- Mitochondria
- cytosol
- apical membrane
- basolateral membrane
- lysosome membrane
- lysosomal compartment
- inner nuclear membrane
- nucleoplasm
- growth cone
- brush border
- perikaryon
- dendrites
- exosomes
- phagosomes
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hsp90ab1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of nitric oxide biosynthetic process
- positive regulation of protein localization at cell surface
- regulation of protein localization
- chaperone-mediated protein folding
- telomere maintenance via telomerase
- positive regulation of cell differentiation
- placenta development
- protein folding
- response to unfolded protein
- cellular response to heat
- positive regulation of phosphoprotein phosphatase activity
- viral attachment to host cell
- negative regulation of apoptotic process
- cellular response to interleukin-4
- chaperone-mediated protein complex assembly
- regulation of protein ubiquitination
- regulation of cell cycle
- protein stabilization
- positive regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- neuronal cell body
- extracellular region
- plasma membrane
- nucleoplasm
- cell surface
- nucleus
- dendritic growth cone
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cytoplasm
- melanosome
- axonal growth cone
- mitochondrion
- membrane
- cytosol
- macromolecular complex
- secretory granule lumen
- aryl hydrocarbon receptor complex
- signalosome
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- peptide binding
- ATP-dependent protein binding
- ATP binding
- DNA polymerase binding
- RNA binding
- protein binding involved in protein folding
- double-stranded RNA binding
- cadherin binding
- protein kinase regulator activity
- kinase binding
- heat shock protein binding
- protein kinase binding
- identical protein binding
- protein homodimerization activity
- histone deacetylase binding
- unfolded protein binding
- protein dimerization activity
- MHC class II protein complex binding
- ubiquitin protein ligase binding
- protein binding
- TPR domain binding
- tau protein binding
- nitric-oxide synthase regulator activity