Lct Gene Summary [Rat]
Enables hydrolase activity, hydrolyzing O-glycosyl compounds and transferase activity. Involved in several processes, including disaccharide catabolic process; glycosylceramide catabolic process; and response to estrogen. Located in brush border. Used to study diarrhea. Biomarker of colitis. Human ortholog(s) of this gene implicated in congenital lactase deficiency. Orthologous to human LCT (lactase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lct |
| Official Name | lactase [Source:RGD Symbol;Acc:620823] |
| Ensembl ID | ENSRNOG00000003681 |
| Bio databases IDs | |
| Aliases | lactase |
| Synonyms | Gm100, LAC, lactase, LPH, LPH1, LPHL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lct often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycosylceramidase
- glucosylceramidase
- enzyme
- cleavage site
- beta-galactosidase
- Glycosyl hydrolase family 1
- beta-glucosidase
- Glycosyl hydrolases
- galactosylceramidase
- transferase
- glycosidase
- protein homodimerization
- lactase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lactose intolerance
- congenital lactase deficiency
- osteoarthritis
- diabetes mellitus
regulates
- cellobiose
- quercetin
- lactose
- glycosylceramide
- LCT
- carbohydrate
role in cell
- response
- homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- plasma membrane extracellular face
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lct gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lactose catabolic process
- glycosylceramide catabolic process
- cellobiose catabolic process
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- glucosylceramidase activity
- galactosylceramidase activity
- protein homodimerization activity
- glycosylceramidase activity
- cellobiose glucosidase activity
- beta-glucosidase activity
- lactase activity