Hoxc11 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in embryonic skeletal joint morphogenesis and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including embryonic digit morphogenesis; organ induction; and regionalization. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human HOXC11 (homeobox C11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hoxc11 |
| Official Name | homeobox C11 [Source:RGD Symbol;Acc:6489991] |
| Ensembl ID | ENSRNOG00000016141 |
| Bio databases IDs | |
| Aliases | homeobox C11 |
| Synonyms | homeobox C11, homeobox protein Hox-C11-like, Hox-3.7, HOX3H, LOC100911859, RGD1305450 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hoxc11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Protein of unknown function (DUF3528)
- protein binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypoplasia
- Ewing sarcoma
- osteosarcomagenesis
- clear cell sarcoma of the kidney
- renal cancer
- soft tissue sarcoma cancer
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hoxc11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- metanephros development
- embryonic skeletal joint morphogenesis
- endoderm development
- anterior/posterior pattern specification
- organ induction
- anatomical structure development
- positive regulation of transcription from RNA polymerase II promoter
- proximal/distal pattern formation
- embryonic digit morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity