Pi4k2b Gene Summary [Rat]
Predicted to enable 1-phosphatidylinositol 4-kinase activity. Predicted to be involved in Golgi organization; endosome organization; and phosphatidylinositol phosphate biosynthetic process. Predicted to be located in bounding membrane of organelle; cytosol; and endoplasmic reticulum membrane. Predicted to be active in endosome; plasma membrane; and trans-Golgi network. Orthologous to human PI4K2B (phosphatidylinositol 4-kinase type 2 beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pi4k2b |
| Official Name | phosphatidylinositol 4-kinase type 2 beta [Source:RGD Symbol;Acc:1359515] |
| Ensembl ID | ENSRNOG00000003924 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol 4-kinase type 2 beta |
| Synonyms | 2610042N09Rik, 4933409G22Rik, phosphatidylinositol 4-kinase type 2 beta, phosphatidylinositol 4-kinase type 2 β, PI4KIIB, PIK42B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pi4k2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- 1-phosphatidylinositol 4-kinase
- Protein Kinases, catalytic domain
- Phosphatidylinositol 3- and 4-kinase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pancreatic cancer
- squamous cell lung cancer
- breast cancer
- prostate cancer
- breast carcinoma
- liver cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- attention deficit hyperactivity disorder
- esophageal cancer
regulates
- RAB8
- MMP14
- RAB7
- RAB5
- phosphatidylinositol
- MHC II
- phosphatidylinositol 4-phosphate
role in cell
- growth
- formation
- loss
- invasiveness
- invasion by
- quantity
- stabilization in
- formation in
- loss in
- antigen presentation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- vesicles
- lysosome
- Golgi Apparatus
- granules
- cytosol
- endoplasmic reticulum membrane
- microsome
- Golgi membrane
- trans Golgi network
- cis Golgi networks
- endosomal membrane
- early endosomes
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pi4k2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endosome organization
- Golgi organization
- phosphatidylinositol phosphorylation
- phosphatidylinositol biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- early endosome membrane
- trans-Golgi network
- endosome
- membrane
- cytosol
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- 1-phosphatidylinositol 4-kinase activity