Map2k2 Gene Summary [Rat]
Enables ATP binding activity and MAP kinase kinase activity. Involved in negative regulation of gene expression; peptidyl-tyrosine phosphorylation; and response to ischemia. Located in cell cortex. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in cardiofaciocutaneous syndrome 4 and small intestine adenocarcinoma. Orthologous to human MAP2K2 (mitogen-activated protein kinase kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map2k2 |
| Official Name | mitogen activated protein kinase kinase 2 [Source:RGD Symbol;Acc:61888] |
| Ensembl ID | ENSRNOG00000020005 |
| Bio databases IDs | |
| Aliases | mitogen activated protein kinase kinase 2 |
| Synonyms | CFC4, ERK ACTIVATOR KINASE 2, MAPKK2, MEK2, mitogen-activated protein kinase kinase 2, MK2, MKK2, p45 MAPK KINASE, PRKMK2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Map2k2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation lip domain
- protein serine/threonine kinase
- protein threonine/tyrosine kinase
- catalytic domain
- MAPK binding site
- ATP binding
- protein binding
- Protein kinase domain
- MAP-kinase scaffold protein
- PDZ-domain binding
- kinase
- MAP kinase kinase
- protein kinase activator
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
Pathways
Biological processes and signaling networks where the Map2k2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Apoptosis Signaling
- BER pathway
- Cancer Drug Resistance By Drug Efflux
- CD27 Signaling in Lymphocytes
- CNTF Signaling
- CXCR4 Signaling
- Ephrin A Signaling
- ErbB4 Signaling
- GDNF Family Ligand-Receptor Interactions
- Glucocorticoid Receptor Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- Mouse Embryonic Stem Cell Pluripotency
- Neurotrophin/TRK Signaling
- Oncostatin M Signaling
- PAK Signaling
- PDGF Signaling
- Rac Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Renal Cell Carcinoma Signaling
- Role of IL-17A in Arthritis
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- TGF-β Signaling
- UVC-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- progressive glioblastoma
- cancer
- neoplasia
- metastasis
- anaplastic astrocytoma
- metastatic cutaneous melanoma
- Langerhans cell histiocytosis of lung
- cutaneous melanoma
- metastatic gallbladder cancer
role in cell
- migration
- proliferation
- expression in
- phosphorylation in
- growth
- cell death
- differentiation
- cell viability
- production in
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- focal adhesions
- cell cortex
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- microtubules
- intercellular junctions
- cytosol
- cytoplasmic face of plasma membrane
- early endosomes
- late endosomes
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Map2k2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- trachea formation
- Schwann cell development
- ERBB2-ERBB3 signaling pathway
- insulin-like growth factor receptor signaling pathway
- regulation of axon regeneration
- myelination
- face development
- epithelial cell proliferation involved in lung morphogenesis
- thymus development
- regulation of Golgi inheritance
- ERK1 and ERK2 cascade
- MAPK cascade
- heart development
- positive regulation of axonogenesis
- thyroid gland development
- positive regulation of transcription, DNA-dependent
- positive regulation of gene expression
- regulation of stress-activated MAPK cascade
- positive regulation of protein serine/threonine kinase activity
- positive regulation of cell motility
- regulation of early endosome to late endosome transport
Cellular Component
Where in the cell the gene product is active
- late endosome
- endoplasmic reticulum
- Golgi apparatus
- extracellular region
- internal side of plasma membrane
- microtubule
- peroxisomal membrane
- nucleus
- early endosome
- perinuclear region of cytoplasm
- cell-cell junction
- focal adhesion
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- ATP binding
- protein tyrosine kinase activity
- protein binding
- protein serine/threonine kinase activator activity
- protein serine/threonine/tyrosine kinase activity
- metal ion binding
- PDZ domain binding
- MAP kinase kinase activity
- MAP-kinase scaffold activity
- protein serine/threonine kinase activity