Atp2b1 Gene Summary [Rat]
Enables PDZ domain binding activity. Involved in several processes, including calcium ion export; cellular response to corticosterone stimulus; and cellular response to vitamin D. Located in several cellular components, including basolateral plasma membrane; dendritic spine membrane; and neuronal cell body membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone membrane. Biomarker of heroin dependence and hypertension. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 66. Orthologous to human ATP2B1 (ATPase plasma membrane Ca2+ transporting 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp2b1 |
| Official Name | ATPase plasma membrane Ca2+ transporting 1 [Source:RGD Symbol;Acc:621303] |
| Ensembl ID | ENSRNOG00000004026 |
| Bio databases IDs | |
| Aliases | ATPase plasma membrane Ca2+ transporting 1 |
| Synonyms | 2810442I22RIK, ATPase, Ca++ transporting, plasma membrane 1, ATPase plasma membrane Ca2+ transporting 1, Brain Calcium-Transporting Plasma Membrane Type ATPase Class 1 Isoform, CALCIUM PUMPING ATPASE, E130111D10RIK, MRD66, PMCA1, Pmca1a, Pmca1ab, Pmca1b, Pmca1c, PMCA1kb, Similar to plasma membrane calcium pump 1b |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp2b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cation transporter/ATPase, N-terminus
- Ca2+-transporting ATPase
- calcium ion transporter
- sarco/endoplasmic reticulum calcium-translocating P-type ATPase
- heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase
- heavy metal translocating P-type ATPase
- protein binding
- E1-E2 ATPase
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- copper-(or silver)-translocating P-type ATPase
- ATPase
- Plasma membrane calcium transporter ATPase C terminal
- PDZ-domain binding
- plasma-membrane calcium-translocating P-type ATPase
- phospholipid-translocating P-type ATPase, flippase
- Na,H/K antiporter P-type ATPase alpha subunit
- K+-transporting ATPase, B subunit
- potassium and/or sodium efflux P-type ATPase, fungal-type
- Cation transport ATPase (P-type)
- loop domain
- Haloacid Dehalogenase-like Hydrolases
- transporter
- haloacid dehalogenase-like hydrolase
- Cation transporting ATPase, C-terminus
Pathways
Biological processes and signaling networks where the Atp2b1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- cancer
- abdominal cancer
- hypertension
- liver neoplasia
- heart disease
- liver cancer
- digestive system cancer
- epithelial cancer
- epithelial neoplasia
regulates
- Ca2+
- ion
- cytokine
role in cell
- cell death
- quantity
- number
- extension
- homeostasis in
- mobilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microsomal fraction
- detergent-soluble membrane fractions
- pH resistant lipid raft fraction
- synaptic vesicle membrane
- glutaminergic synapse
- apical compartment
- cellular membrane
- Nucleus
- immunological synapses
- cytoplasmic face of plasma membrane
- apical membrane
- presynaptic membrane
- basolateral membrane
- nucleoplasm
- dendritic spines
- synapse
- perikaryon
- dendrites
- ribbon synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp2b1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cellular response to insulin stimulus
- ion transmembrane transport
- positive regulation of calcium ion transport
- cytosolic calcium ion homeostasis
- reduction of cytosolic calcium ion concentration
- regulation of vascular smooth muscle contraction
- negative regulation of cytokine production
- regulation of blood pressure
- positive regulation of bone mineralization
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- membrane
- synaptic vesicle membrane
- cell projection
- basolateral plasma membrane
- plasma membrane
- nucleoplasm
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- calmodulin binding
- protein binding
- metal ion binding
- calcium ion transmembrane transporter activity
- PDZ domain binding
- calcium-transporting ATPase activity