Atp2b1

Predicted to enable several functions, including ATP hydrolysis activity; P-type calcium transporter activity; and PDZ domain binding activity. Involved in several processes, including positive regulation of bone mineralization; regulation of cytosolic calcium ion concentration; and regulation of vascular associated smooth muscle contraction. Located in basolateral plasma membrane; immunological synapse; and synaptic vesicle membrane. Is active in glutamatergic synapse; photoreceptor ribbon synapse; and presynaptic membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study frontotemporal dementia and frontotemporal dementia and/or amyotrophic lateral sclerosis 7. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 66. Orthologous to human ATP2B1 (ATPase plasma membrane Ca2+ transporting 1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp2b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Atp2b1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp2b1 gene, providing context for its role in the cell.