Nectin4 Gene Summary [Rat]
Predicted to enable identical protein binding activity and receptor ligand activity. Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and negative regulation of natural killer cell mediated cytotoxicity. Predicted to be located in plasma membrane. Predicted to be active in adherens junction. Orthologous to human NECTIN4 (nectin cell adhesion molecule 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nectin4 |
| Official Name | nectin cell adhesion molecule 4 [Source:RGD Symbol;Acc:1559826] |
| Ensembl ID | ENSRNOG00000004029 |
| Bio databases IDs | |
| Aliases | nectin cell adhesion molecule 4 |
| Synonyms | 1200017F15Rik, EDSS1, LNIR, nectin cell adhesion molecule 4, PRR4, PVRL4, RGD1559826 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nectin4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- ectodomain
- Immunoglobulin like
- Immunoglobulin I-set domain
- receptor agonist activity
- protein binding
- Ig-like V domain
- identical protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- mixed urothelial bladder carcinoma
- urothelial urethral cancer
- urothelial cancer
- mixed urothelial urethral carcinoma
- urethral squamous cell carcinoma
- transitional cell bladder cancer
- bladder squamous cell carcinoma
- ureter squamous cell carcinoma
- urothelial bladder carcinoma
role in cell
- activation in
- replication in
- formation
- growth
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- intercellular junctions
- apical cell surfaces
- basolateral cell surfaces
- lateral plasma membrane
- intercalated disks
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nectin4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- heterophilic cell-cell adhesion
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- adherens junction
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- viral receptor activity