Nectin3 Gene Summary [Rat]
Predicted to enable cell adhesion mediator activity and protein homodimerization activity. Predicted to be involved in several processes, including cochlea morphogenesis; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to act upstream of or within several processes, including camera-type eye morphogenesis; fertilization; and protein localization to cell junction. Located in axon and dendrite. Orthologous to human NECTIN3 (nectin cell adhesion molecule 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nectin3 |
| Official Name | nectin cell adhesion molecule 3 [Source:RGD Symbol;Acc:1309516] |
| Ensembl ID | ENSRNOG00000002176 |
| Bio databases IDs | |
| Aliases | nectin cell adhesion molecule 3 |
| Synonyms | 2610301B19Rik, 3000002N23Rik, 4921513D19Rik, CD113, CDW113, LOC100506575, nectin cell adhesion molecule 3, PPR3, PRR3, PVRL3, PVRR3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nectin3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Immunoglobulin V-Type
- immunoglobulin domain
- cell adhesion molecule binding
- TM_EGFR-like
- Immunoglobulin I-set domain
- protein binding
- identical protein binding
- Immunoglobulin like
- protein homodimerization
- cytosolic tail domain
- PDZ binding motif
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Nectin3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- microphthalmia
- congenital cataract
- colon cancer
- myopia
- ischemic stroke
- memory deficits
- latent tuberculosis
role in cell
- migration
- formation
- abnormal morphology
- cell-cell adhesion
- fertilization
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- spot-like adhesion site
- cell surface
- cellular membrane
- intercellular junctions
- cell-cell contacts
- microsome
- postsynaptic membrane
- synaptic membrane
- synaptosomes
- synapse
- anchoring junction
- axons
- dendrites
- postsynaptic terminals
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nectin3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- retina morphogenesis in camera-type eye
- heterophilic cell-cell adhesion
- fertilization
- homophilic cell adhesion
- lens morphogenesis in camera-type eye
Cellular Component
Where in the cell the gene product is active
- dendrite
- cell-cell contact zone
- adherens junction
- cell-cell junction
- apical junction complex
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- cell adhesion molecule binding