Nectin1 Gene Summary [Rat]
Enables carbohydrate binding activity and virion binding activity. Involved in axon guidance; regulation of synapse assembly; and symbiont entry into host cell. Located in dendrite and growth cone membrane. Human ortholog(s) of this gene implicated in cleft lip; cleft lip-palate-ectodermal dysplasia syndrome; cleft palate; and ectodermal dysplasia. Orthologous to human NECTIN1 (nectin cell adhesion molecule 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nectin1 |
| Official Name | nectin cell adhesion molecule 1 [Source:RGD Symbol;Acc:620791] |
| Ensembl ID | ENSRNOG00000006403 |
| Bio databases IDs | |
| Aliases | nectin cell adhesion molecule 1 |
| Synonyms | CD111, CLPED1, ED4, HIgR, HV1S, HVEC, MGC16207, Nectin1 δ, nectin cell adhesion molecule 1, OFC7, PRR, PRR1, PVRL1, PVRR, PVRR1, SK-12 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nectin1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- virion binding
- soluble domain
- signaling receptor activity
- viral receptor
- Immunoglobulin V-Type
- immunoglobulin domain
- cell adhesion molecule binding
- TM_EGFR-like
- protein binding
- V domain
- identical protein binding
- Ig-like V domain
- binding protein
- cytoplasmic domain
- Immunoglobulin like
- transmembrane domain
- protein homodimerization
- carbohydrate binding
- Immunoglobulin V-set domain
- coreceptor
Pathways
Biological processes and signaling networks where the Nectin1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- endometriosis
- Zlotogora-Ogur syndrome
- rheumatoid arthritis
- orofacial cleft 7
- early missed abortion
- eyelids open at birth
- microphthalmia
- encephalitis
- disorder of pregnancy
role in cell
- formation
- adhesion
- morphology
- guidance
- abnormal morphology
- cell-cell adhesion
- entrance
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endoplasmic reticulum/Golgi apparatus fractions
- myelin enriched fraction
- synaptic plasma membrane fractions
- detergent-insoluble fractions
- spot-like adhesion site
- presynaptic regions
- cell surface
- Extracellular Space
- cellular membrane
- intercellular junctions
- cell-cell contacts
- microsome
- presynaptic membrane
- lateral plasma membrane
- growth cone
- synaptosomes
- synapse
- anchoring junction
- junctional complexes
- axons
- dendrites
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nectin1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- retina development in camera-type eye
- heterophilic cell-cell adhesion
- axon guidance
- cell adhesion
- homophilic cell adhesion
- lens morphogenesis in camera-type eye
- immune response
- enamel mineralization
- iron ion transport
- desmosome organization
- regulation of synapse assembly
Cellular Component
Where in the cell the gene product is active
- dendrite
- cell-cell contact zone
- adherens junction
- apical junction complex
- membrane
- growth cone membrane
- presynaptic active zone membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- virion binding
- coreceptor activity
- identical protein binding
- protein homodimerization activity
- protein binding
- cell adhesion molecule binding
- viral receptor activity
- carbohydrate binding