Zfp386 Gene Summary [Rat]
Enables double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and spermatogenesis. Predicted to be active in nucleus. Orthologous to human ZNF519 (zinc finger protein 519). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp386 |
| Official Name | zinc finger protein 386 (Kruppel-like) [Source:RGD Symbol;Acc:2985] |
| Ensembl ID | ENSRNOG00000004268 |
| Bio databases IDs | |
| Aliases | zinc finger protein 386 (Kruppel-like) |
| Synonyms | Kzf1, mKIAA4205, zinc finger protein 386 (Kruppel-like), Znf386 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zfp386 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- double-stranded DNA binding
- Zinc-finger double domain
- chromatin binding
- KRAB (Kruppel-associated box) domain -A box
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown