Hnrnpk Gene Summary [Rat]
Enables several functions, including ATPase binding activity; DNA binding activity; and RNA binding activity. Involved in several processes, including gonad development; nervous system development; and regulation of gene expression. Located in axon terminus; cell cortex; and dendritic spine. Part of protein-DNA complex. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in Raynaud disease. Orthologous to human HNRNPK (heterogeneous nuclear ribonucleoprotein K). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hnrnpk |
| Official Name | heterogeneous nuclear ribonucleoprotein K [Source:RGD Symbol;Acc:71058] |
| Ensembl ID | ENSRNOG00000019113 |
| Bio databases IDs | |
| Aliases | heterogeneous nuclear ribonucleoprotein K |
| Synonyms | AUKS, CSBP, heterogeneous nuclear ribonucleoprotein K, HNRPK, KBBP, NOVA, TUNP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hnrnpk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RGG domain
- nucleic acid binding
- mRNA binding
- actinin binding
- heat shock protein binding
- lamin binding
- HCV core protein binding domain
- protein domain specific binding
- K homology RNA-binding domain
- protein binding
- sequence-specific DNA binding
- proline rich domain
- identical protein binding
- RNA binding
- ATPase binding
- mRNA 3' UTR binding
- KH domain
- single-stranded DNA binding
- K homology (KH) RNA-binding domain, type I
- ROKNT (NUC014) domain
- double-stranded DNA binding
- pre-mRNA 3' splice site binding
- ribonucleoprotein binding
Pathways
Biological processes and signaling networks where the Hnrnpk gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ulcerative colitis
- mental retardation
- epithelial cancer
- tumorigenesis
- Au-Kline syndrome
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- hereditary disorder
- mucoepidermoid carcinoma
- melanoma
role in cell
- activation in
- apoptosis
- expression in
- binding in
- phosphorylation in
- proliferation
- production in
- differentiation
- invasion by
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- glutaminergic synapse
- catalytic step 2 spliceosome
- Cytoplasm
- postsynaptic region
- inner membrane
- cell cortex
- Mitochondria
- cytosol
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- dendritic spines
- mitoplasts
- stress granule
- chromatin
- axon terminals
- paraspeckle-like structures
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hnrnpk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- regulation of low-density lipoprotein particle clearance
- signal transduction
- negative regulation of nuclear mRNA splicing, via spliceosome
- negative regulation of apoptotic process
- regulation of nuclear mRNA splicing, via spliceosome
- RNA processing
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of receptor-mediated endocytosis
- nuclear mRNA splicing, via spliceosome
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- extracellular vesicular exosome
- focal adhesion
- catalytic step 2 spliceosome
- cytoplasm
- membrane
- chromatin
- cell projection
- podosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein domain specific binding
- identical protein binding
- protein binding
- RNA binding
- cadherin binding
- mRNA binding