Ttc8 Gene Summary [Rat]
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in establishment of anatomical structure orientation; fat cell differentiation; and non-motile cilium assembly. Predicted to act upstream of or within several processes, including morphogenesis of a polarized epithelium; negative regulation of GTPase activity; and nervous system development. Predicted to be located in several cellular components, including ciliary membrane; fibrillar center; and photoreceptor connecting cilium. Predicted to be part of BBSome. Predicted to be active in ciliary basal body and non-motile cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 8; and retinitis pigmentosa 51. Orthologous to human TTC8 (tetratricopeptide repeat domain 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ttc8 |
| Official Name | tetratricopeptide repeat domain 8 [Source:RGD Symbol;Acc:1307769] |
| Ensembl ID | ENSRNOG00000004542 |
| Bio databases IDs | |
| Aliases | tetratricopeptide repeat domain 8 |
| Synonyms | 0610012F22Rik, BBS8, RP51, tetratricopeptide repeat domain 8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ttc8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tetratricopeptide repeats
- transcription factor binding
- protein binding
- tetratricopeptide repeat
- dermokine
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Bardet-Biedl syndrome
- hereditary disorder
- retinitis pigmentosa type 51
- retinal dystrophy
- Bardet-Biedl syndrome type 8
- ciliopathy
role in cell
- differentiation
- assembly
- formation
- organization
- guidance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- cilia
- cellular membrane
- basal bodies
- centrosome
- Mitochondria
- cytosol
- connecting cilia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ttc8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- inner ear receptor stereocilium organization
- cilium morphogenesis
- regulation of protein localization
- protein transport
- axon guidance
- regulation of stress fiber assembly
- camera-type eye photoreceptor cell differentiation
- fat cell differentiation
- olfactory bulb development
- renal tubule development
- establishment of anatomical structure orientation
- sensory processing
- establishment of epithelial cell apical/basal polarity
- sensory perception of smell
- establishment of planar polarity
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- centrosome
- BBSome
- cilium basal body
- centriolar satellite
- cilium
- cytosol
- cilium membrane
Molecular Function
What the gene product does at the molecular level
- protein binding