Stx3 Gene Summary [Rat]
Enables SNAP receptor activity and arachidonate binding activity. Involved in membrane fusion and neuron projection development. Located in growth cone and plasma membrane. Part of SNARE complex. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human STX3 (syntaxin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stx3 |
| Official Name | syntaxin 3 [Source:RGD Symbol;Acc:621005] |
| Ensembl ID | ENSRNOG00000021013 |
| Bio databases IDs | |
| Aliases | syntaxin 3 |
| Synonyms | DIAR12, MVID2, RDMVID, STX3A, Syn-3, syntaxin 3, Syntaxin 3A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNAP receptor
- coiled-coil domain
- arachidonic acid binding
- protein binding
- SynN
- cytoplasmic domain
- SNARE domain
- Helical region found in SNAREs
- transmembrane domain
- Syntaxin
- SNARE motif
- golgi targeting sequence
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- uterine leiomyoma
- retinal dystrophy and microvillus inclusion disease
- HER2 negative hormone receptor negative breast cancer
- systemic sclerosis
- leiomyomatosis
- diarrhea with microvillus atrophy type 12
role in cell
- proliferation
- survival
- upregulation in
- abnormal morphology
- adhesion
- fusion
- exocytosis by
- chemotaxis
- morphogenesis
- downregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- invadopodia
- presynaptic regions
- postsynaptic region
- cellular membrane
- vacuole
- intercellular junctions
- granules
- cytosol
- apical membrane
- nucleoplasm
- zymogen granules
- growth cone
- neurites
- nerve ending
- synapse
- photoreceptor outer segments
- photoreceptor inner segments
- vacuolar apical compartments
- melanosomes
- azurophil granules
- specific granules
- secretory granules
- dendrites
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stx3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein localization at cell surface
- neuron projection development
- vesicle docking
- synaptic vesicle fusion to presynaptic membrane
- positive regulation of cell proliferation
- regulation of gene expression
- long-term synaptic potentiation
- positive regulation of cell adhesion
- organelle membrane fusion
- intracellular protein transport
- positive regulation of chemotaxis
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- presynaptic active zone membrane
- neuron projection
- vacuole
- zymogen granule membrane
- plasma membrane
- photoreceptor outer segment
- growth cone
- dendrite
- nucleus
- cell-cell junction
- extracellular vesicular exosome
- melanosome
- specific granule
- azurophil granule
- endomembrane system
- SNARE complex
- photoreceptor inner segment
- apical plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- SNAP receptor activity
- SNARE binding
- arachidonic acid binding