Tpo Gene Summary [Rat]
Predicted to enable iodide peroxidase activity. Involved in cellular response to nitric oxide and response to lipid. Located in cell surface. Human ortholog(s) of this gene implicated in congenital hypothyroidism; glomerulonephritis; and thyroid dyshormonogenesis 2A. Orthologous to human TPO (thyroid peroxidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tpo |
| Official Name | thyroid peroxidase [Source:RGD Symbol;Acc:3900] |
| Ensembl ID | ENSRNOG00000004646 |
| Bio databases IDs | |
| Aliases | thyroid peroxidase |
| Synonyms | MSA, TDH2A, Thyroid peroxidase, Thyroperoxidase, TPX |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tpo often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Animal haem peroxidase
- enzyme
- Animal heme peroxidases and related proteins
- iodide peroxidase
- EGF-like domain
- EGF_CA
- CCP
- peroxidase
- sushi-like domain
- peroxidase (miscellaneous)
- EGF domain
- Sushi repeat (SCR repeat)
- SUSHI repeat
Pathways
Biological processes and signaling networks where the Tpo gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- deficiency of iodide peroxidase
- thyroid oncocytic carcinoma
- Hurthle cell thyroid cancer
- thyroid disease
- papillary thyroid carcinoma
- papillary thyroid cancer
- follicular thyroid carcinoma
- follicular thyroid cancer
- follicular papillary thyroid carcinoma
role in cell
- phosphorylation in
- expression in
- activation in
- proliferation
- activation
- cross-sectional area
- signaling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tpo gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- embryonic hemopoiesis
- thyroid hormone generation
- hormone biosynthetic process
- hydrogen peroxide catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- iodide peroxidase activity
- peroxidase activity
- calcium ion binding
- heme binding