Eif4e Gene Summary [Rat]
Enables eukaryotic initiation factor 4G binding activity. Involved in lung development. Part of eukaryotic translation initiation factor 4F complex. Is active in glutamatergic synapse and postsynaptic cytosol. Biomarker of vascular dementia. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EIF4E (eukaryotic translation initiation factor 4E). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eif4e |
| Official Name | eukaryotic translation initiation factor 4E [Source:RGD Symbol;Acc:69647] |
| Ensembl ID | ENSRNOG00000052343 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 4E |
| Synonyms | AUTS19, CAP-binding, CBP, EG668879, EIF4E1, EIF4EL1, Eif4e-ps, EIF4F, eukaryotic translation initiation factor 4E, If4e |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eif4e often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA cap binding
- mRNA binding
- enzyme binding
- transcription factor binding
- protein binding
- translation regulator
- cap-binding domain
- phosphorylation site
- Eukaryotic initiation factor 4E
- RNA 7-methylguanosine cap binding
- serine phosphorylation site
- translation initiation factor
- hydrophobic domain
- eukaryotic initiation factor 4G binding
Pathways
Biological processes and signaling networks where the Eif4e gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Cardiac Hypertrophy Signaling
- Circadian Rhythm Signaling
- EIF2 Signaling
- ERK/MAPK Signaling
- Estrogen Receptor Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- HIF1α Signaling
- Insulin Receptor Signaling
- mTOR Signaling
- PI3K/AKT Signaling
- Regulation of eIF4 and p70S6K Signaling
- Role of Tissue Factor in Cancer
- UVB-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- neoplasia
- mantle cell lymphoma
- prostatic intraepithelial neoplasia
- organismal death
- neoplastic cell transformation
- mechanical hypersensitivity
- psoriasis
- susceptibility to autism type 19
- bladder cancer
role in cell
- binding in
- phosphorylation in
- expression in
- differentiation
- degradation in
- growth
- cell viability
- proliferation
- density
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- soluble fraction
- multicilium
- GW body
- glutaminergic synapse
- cytoplasmic ribonucleoprotein granule
- cytoplasmic mRNA processing body
- perinuclear region
- postsynaptic region
- cellular membrane
- membrane skeleton
- Nucleus
- cytosol
- sister chromatids
- nuclear bodies
- nuclear speckles
- synaptosomes
- synapse
- stress granule
- pseudopodia
- PML nuclear bodies
- perikaryon
- dendrites
- postsynaptic density
- excitatory synapses
- dendritic shafts
- sensory axons
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eif4e gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stem cell maintenance
- neuron differentiation
- negative regulation of neuron differentiation
- translational initiation
- positive regulation of mitotic cell cycle
- behavioral fear response
- regulation of translation
- mRNA export from nucleus
- negative regulation of autophagy
- G1/S transition of mitotic cell cycle
- cellular response to dexamethasone stimulus
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatoid body
- extracellular vesicular exosome
- cytoplasmic stress granule
- perinuclear region of cytoplasm
- eukaryotic translation initiation factor 4F complex
- cytoplasm
- nuclear speck
- cytosol
- cytoplasmic mRNA processing body
- RNA-induced silencing complex
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- RNA 7-methylguanosine cap binding
- RNA binding
- protein binding
- eukaryotic initiation factor 4G binding
- RNA cap binding
- enzyme binding