Cyp4f1 Gene Summary [Rat]
Enables arachidonate binding activity; heme binding activity; and monooxygenase activity. Involved in leukotriene B4 catabolic process; omega-hydroxylase P450 pathway; and response to toxic substance. Predicted to be located in endoplasmic reticulum membrane. Biomarker of hypertension. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to several human genes including CYP4F2 (cytochrome P450 family 4 subfamily F member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp4f1 |
| Official Name | cytochrome P450, family 4, subfamily f, polypeptide 1 [Source:RGD Symbol;Acc:70926] |
| Ensembl ID | ENSRNOG00000004786 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 4, subfamily f, polypeptide 1 |
| Synonyms | 1300014O15Rik, Cyp4f1, Cyp4f2, cytochrome P450, family 4, subfamily f, polypeptide 1, cytochrome P450, family 4, subfamily f, polypeptide 14 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyp4f1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- reduced flavin or flavoprotein:oxygen oxidoreductase
- fatty acid binding
- leukotriene-B4 20-monooxygenase
- arachidonic acid binding
- enzyme
- heme binding
- arachidonic acid epoxygenase
- NADH2 or NADPH2 1 atom incorporation:oxygen oxidoreductase
- alkane 1-monooxygenase
- arachidonic acid monooxygenase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Endoplasmic Reticulum
- apical membrane