Cntn4 Gene Summary [Rat]
Predicted to enable cell-cell adhesion mediator activity. Involved in brain development and neuron projection development. Predicted to be located in extracellular region and side of membrane. Predicted to be active in axon; plasma membrane; and synapse. Orthologous to human CNTN4 (contactin 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cntn4 |
| Official Name | contactin 4 [Source:RGD Symbol;Acc:621361] |
| Ensembl ID | ENSRNOG00000005652 |
| Bio databases IDs | |
| Aliases | contactin 4 |
| Synonyms | AXCAM, BIG-2, contactin 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cntn4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- FN3
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- Fibronectin type 3 domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- amyotrophic lateral sclerosis
- epithelial cancer
- atypical femur fracture
- atherosclerosis
- schizophrenia
- idiopathic scoliosis
- thoracic aortic aneurysm
- major depression
- bipolar disorder
- pervasive developmental disorder
regulated by
- budesonide
role in cell
- differentiation
- development
- guidance
- morphogenesis
- plasticity
- fasciculation
- cell-cell adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cntn4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron projection development
- synapse organization
- negative regulation of neuron differentiation
- nervous system development
- axon guidance
- neuron cell-cell adhesion
- homophilic cell adhesion
- brain development
- axonal fasciculation
- axonogenesis
- dendrite self-avoidance
- regulation of synaptic plasticity
Cellular Component
Where in the cell the gene product is active
- synapse
- extracellular region
- plasma membrane
- axon