Tbc1d20 Gene Summary [Rat]
Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in several processes, including COPII-coated vesicle cargo loading; positive regulation by host of viral genome replication; and positive regulation by virus of viral protein levels in host cell. Predicted to act upstream of or within several processes, including acrosome assembly; lens fiber cell morphogenesis; and seminiferous tubule development. Predicted to be located in Golgi membrane; endoplasmic reticulum membrane; and nuclear membrane. Human ortholog(s) of this gene implicated in Warburg micro syndrome 4. Orthologous to human TBC1D20 (TBC1 domain family member 20). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbc1d20 |
| Official Name | TBC1 domain family, member 20 [Source:RGD Symbol;Acc:1303293] |
| Ensembl ID | ENSRNOG00000005766 |
| Bio databases IDs | |
| Aliases | TBC1 domain family, member 20 |
| Synonyms | 1110028I04Rik, 2810442O16RIK, AI414693, bs, C20orf140, PRP6, TBC1 domain family member 20, TBC1 domain family, member 20, WARBM4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tbc1d20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab-GTPase-TBC domain
- Domain in Tre-2, BUB2p, and Cdc16p
- enzyme binding
- GTPase activator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- Golgi membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tbc1d20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acrosome assembly
- ER to Golgi vesicle-mediated transport
- lens fiber cell morphogenesis
- seminiferous tubule development
- Golgi organization
- cargo loading into COPII-coated vesicle
- virion assembly
- lipid particle organization
- positive regulation of viral protein levels in host cell
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
- Golgi membrane
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- small GTPase binding