Nup88 Gene Summary [Rat]
Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nucleocytoplasmic transport. Part of nuclear pore. Human ortholog(s) of this gene implicated in fetal akinesia deformation sequence syndrome 4. Orthologous to human NUP88 (nucleoporin 88). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nup88 |
| Official Name | nucleoporin 88 [Source:RGD Symbol;Acc:620182] |
| Ensembl ID | ENSRNOG00000006126 |
| Bio databases IDs | |
| Aliases | nucleoporin 88 |
| Synonyms | FADS4, nucleoporin 88, Nucleoporin Nup88, Nup84, PREI2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nup88 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of nuclear pore
- Nuclear pore component
- protein binding
Pathways
Biological processes and signaling networks where the Nup88 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- fetal akinesia deformation sequence 4
role in cell
- cell death
- misalignment
- misalignment in
- reorganization in
- reorganization
- retention in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- detergent resistant lipid raft fraction
- Cytoplasm
- cytosol
- nuclear foci
- nuclear pores
- inner nuclear membrane
- nucleoplasm
- outer nuclear membrane
- nuclear rim
- nuclear envelope
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nup88 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosomal small subunit export from nucleus
- mRNA export from nucleus
- ribosomal large subunit export from nucleus
- nucleocytoplasmic transport
- protein import into nucleus
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- cytosol
- nuclear pore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of nuclear pore