Nup98 Gene Summary [Rat]
Enables nuclear localization sequence binding activity. Involved in protein import into nucleus. Located in nucleus. Part of nuclear pore nuclear basket. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Orthologous to human NUP98 (nucleoporin 98 and 96 precursor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nup98 |
| Official Name | nucleoporin 98 [Source:RGD Symbol;Acc:71033] |
| Ensembl ID | ENSRNOG00000020347 |
| Bio databases IDs | |
| Aliases | nucleoporin 98 |
| Synonyms | 4732457F17, ADIR2, AI849286, nucleoporin 98, nucleoporin 98 and 96 precursor, NUP196, NUP96, Nup98-96 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nup98 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein repeat
- peptide binding
- transcription co-activator
- mRNA binding
- Nuclear protein 96
- protein binding activity, bridging
- chromatin binding
- enzyme
- protein binding
- nuclear localization sequence binding
- Nucleoporin autopeptidase
- structural constituent of nuclear pore
- Nucleoporin FG repeat region
- GLFG repeat
- FG rich domain
- Nucleoporin homology of Germinal-centre associated nuclear protein
Pathways
Biological processes and signaling networks where the Nup98 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- liver cancer
- Alzheimer disease
- Hirschsprung disease 1
- T acute lymphoblastic leukemia
- non-insulin-dependent diabetes mellitus
- primary myelofibrosis
- obesity
- breast adenocarcinoma
- non-small cell lung cancer
role in cell
- binding
- expression in
- number
- accumulation in
- production in
- proliferation
- quantity
- apoptosis
- activation in
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nuclear membrane fraction
- spindle apparatus
- intranuclear region
- perinuclear region
- centriole
- cytosol
- nuclear foci
- nuclear pores
- inner nuclear membrane
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear rim
- spindle pole
- nuclear envelope
- nucleoplasmic baskets
- kinetochores
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nup98 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleocytoplasmic transport
- nuclear pore organization
- RNA export from nucleus
- telomere tethering at nuclear periphery
- positive regulation of nuclear mRNA splicing, via spliceosome
- positive regulation of transcription, DNA-dependent
- protein import into nucleus
- proteolysis
- nuclear pore complex assembly
- posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear inclusion body
- nuclear membrane
- Nup107-160 complex
- nuclear body
- cytosol
- kinetochore
- nuclear periphery
- nuclear pore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- transcription coactivator activity
- serine-type peptidase activity
- structural constituent of nuclear pore
- mRNA binding
- nuclear localization sequence binding