Etaa1 Gene Summary [Rat]
Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including positive regulation of protein serine/threonine kinase activity; regulation of cell cycle phase transition; and replication fork processing. Predicted to be located in cytosol; nuclear speck; and plasma membrane. Predicted to be active in nuclear replication fork. Orthologous to human ETAA1 (ETAA1 activator of ATR kinase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Etaa1 |
| Official Name | ETAA1 activator of ATR kinase [Source:RGD Symbol;Acc:1587340] |
| Ensembl ID | ENSRNOG00000006185 |
| Bio databases IDs | |
| Aliases | ETAA1 activator of ATR kinase |
| Synonyms | 5730466H23Rik, ETAA16, ETAA1 activator of ATR kinase, Etaa1l1, Ewing tumor-associated antigen 1, Ewing tumour-associated antigen 1, LOC103693794, LOC680614, RGD1560957 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Etaa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- replication protein A binding domain
- protein binding
- Ewing's tumour-associated antigen 1 homolog
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear speckles
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Etaa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- replication fork processing
- regulation of DNA damage checkpoint
- response to DNA damage stimulus
- positive regulation of protein serine/threonine kinase activity
Cellular Component
Where in the cell the gene product is active
- nuclear replication fork
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein serine/threonine kinase activator activity