Thumpd3 Gene Summary [Rat]
Predicted to enable tRNA (guanine(6)-N2)-methyltransferase activity and tRNA (guanine(7)-N2)-methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to be located in cytosol and nucleolus. Predicted to be part of tRNA methyltransferase complex. Orthologous to human THUMPD3 (THUMP domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Thumpd3 |
| Official Name | THUMP domain containing 3 [Source:RGD Symbol;Acc:1560852] |
| Ensembl ID | ENSRNOG00000006941 |
| Bio databases IDs | |
| Aliases | THUMP domain containing 3 |
| Synonyms | Gtrosa26as, Gt(ROSA)26asSor, RGD1560852, THUMP domain 3 tRNA guanosine methyltransferase, THUMP domain containing 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Thumpd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA (guanine) methyltransferase
- THUMP domain, predicted to bind RNA
- enzyme
- protein binding
- AdoMet_MTases
- methyltransferase domain
- N-methyltransferase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Thumpd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA methylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- tRNA binding
- tRNA (guanine) methyltransferase activity