Acot11 Gene Summary [Rat]
Predicted to enable long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process; negative regulation of cold-induced thermogenesis; and response to cold. Predicted to be located in mitochondrial matrix. Predicted to be active in cytosol. Orthologous to human ACOT11 (acyl-CoA thioesterase 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acot11 |
| Official Name | acyl-CoA thioesterase 11 [Source:RGD Symbol;Acc:2324815] |
| Ensembl ID | ENSRNOG00000007837 |
| Bio databases IDs | |
| Aliases | acyl-CoA thioesterase 11 |
| Synonyms | 1110020M10Rik, 2010309H15Rik, acyl-CoA thioesterase 11, BFIT, BFIT1, mKIAA0707, STARD14, THEA, THEM1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acot11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SRPBCC domain
- Thioesterase superfamily
- hot_dog
- enzyme
- protein binding
- acyl-CoA hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
- obesity
- Huntington disease
- overall survival
- hepatic steatosis
role in cell
- abnormal morphology
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acot11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acyl-CoA metabolic process
- response to cold
- response to temperature stimulus
- fatty acid metabolic process
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- mitochondrial matrix
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- long-chain acyl-CoA hydrolase activity
- lipid binding
- acyl-CoA hydrolase activity
- carboxylic ester hydrolase activity