Nagk Gene Summary [Rat]
Predicted to enable N-acetylglucosamine kinase activity; N-acylmannosamine kinase activity; and muramyl dipeptide kinase activity. Predicted to be involved in several processes, including N-acetylglucosamine catabolic process; UDP-N-acetylglucosamine biosynthetic process; and positive regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway. Predicted to act upstream of or within N-acetylglucosamine metabolic process. Orthologous to human NAGK (N-acetylglucosamine kinase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nagk |
| Official Name | N-acetylglucosamine kinase [Source:RGD Symbol;Acc:1305057] |
| Ensembl ID | ENSRNOG00000013911 |
| Bio databases IDs | |
| Aliases | N-acetylglucosamine kinase |
| Synonyms | GNK, HSA242910, N-acetylglucosamine kinase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nagk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- N-acylmannosamine kinase
- N-acetylglucosamine kinase
- protein binding
- ASKHA_ATPase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- neoplasia
- acute graft-vs-host disease
- atopic dermatitis
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- systemic sclerosis
regulates
- N-acetylneuraminic acid
- N-acetylglucosamine
- N-acetylmannosamine
- STK16
- UDP-N-acetylglucosamine
role in cell
- branching
- branching in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- perinuclear region
- vesicles
- cytosol
- filopodia
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nagk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to muramyl dipeptide
- N-acetylneuraminate catabolic process
- N-acetylmannosamine metabolic process
- innate immune response
- positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
- N-acetylglucosamine metabolic process
- carbohydrate phosphorylation
- defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- N-acetylglucosamine kinase activity