Acox2 Gene Summary [Rat]
Enables 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Involved in fatty acid beta-oxidation. Located in peroxisome. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 6. Orthologous to human ACOX2 (acyl-CoA oxidase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acox2 |
| Official Name | acyl-CoA oxidase 2 [Source:RGD Symbol;Acc:628684] |
| Ensembl ID | ENSRNOG00000007378 |
| Bio databases IDs | |
| Aliases | acyl-CoA oxidase 2 |
| Synonyms | acyl-CoA oxidase 2, acyl-Coenzyme A oxidase 2, branched chain, BCOX, BRCACOX, BRCOX, CBAS6, THCCox, Trihydroxycoprostanoyl-CoA Oxidase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acox2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acyl-CoA oxidase
- flavin adenine dinucleotide binding
- acyl-CoA dehydrogenase
- Acyl-CoA dehydrogenase, middle domain
- fatty acid binding
- Acyl-coenzyme A oxidase N-terminal
- protein homodimerization
- enzyme
- protein binding
- CH2 group oxidoreductase
Pathways
Biological processes and signaling networks where the Acox2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- squamous cell lung cancer
- lung squamous cell carcinoma
- prostate cancer
- prostatic adenocarcinoma
- rheumatoid arthritis
- congenital bile acid synthesis defect type 6
- renal cell cancer
- hepatocellular carcinoma
regulates
- fatty acid
- pristanoyl-coenzyme A
- 2-methylhexanoyl-coenzyme A
- trihydroxycoprostanoyl-coenzyme A
- bile acid
- 2-methylpalmitoyl-coenzyme A
role in cell
- adipogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- intracellular membrane-bounded organelle
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acox2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation using acyl-CoA oxidase
- lipid homeostasis
- bile acid biosynthetic process
- very long-chain fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- intracellular membrane-bounded organelle
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- FAD binding
- fatty acid binding
- protein binding
- protein homodimerization activity
- flavin adenine dinucleotide binding
- 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity
- palmitoyl-CoA oxidase activity