Igsf8 Gene Summary [Rat]
Predicted to enable signaling receptor activity. Predicted to be involved in modulation of chemical synaptic transmission and positive regulation of cell migration. Predicted to act upstream of or within regulation of cell motility. Is active in hippocampal mossy fiber to CA3 synapse and presynaptic membrane. Orthologous to human IGSF8 (immunoglobulin superfamily member 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Igsf8 |
| Official Name | immunoglobulin superfamily, member 8 [Source:RGD Symbol;Acc:1311500] |
| Ensembl ID | ENSRNOG00000007604 |
| Bio databases IDs | |
| Aliases | immunoglobulin superfamily, member 8 |
| Synonyms | CD316, CD81P3, ESTM34, EWI-2, immunoglobulin superfamily member 8, immunoglobulin superfamily, member 8, KCT-4, LIR-D1, PGRL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Igsf8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- cytoplasmic domain
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- intracellular membrane-bounded organelle
- cell surface
- cellular membrane
- uropod
- presynaptic membrane
- synapse
- microsomal membrane
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Igsf8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell motility
- skeletal muscle tissue development
- nervous system development
- single fertilization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding