Snrpd1 Gene Summary [Rat]
Enables U1 snRNP binding activity. Predicted to be involved in spliceosomal snRNP assembly. Part of U1 snRNP. Used to study nephritis; proteinuria; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in connective tissue disease; nephritis; proteinuria; and systemic lupus erythematosus. Orthologous to human SNRPD1 (small nuclear ribonucleoprotein D1 polypeptide). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Snrpd1 |
| Official Name | small nuclear ribonucleoprotein D1 polypeptide [Source:RGD Symbol;Acc:1306345] |
| Ensembl ID | ENSRNOG00000013714 |
| Bio databases IDs | |
| Aliases | small nuclear ribonucleoprotein D1 polypeptide |
| Synonyms | HsT2456, small nuclear ribonucleoprotein D1, small nuclear ribonucleoprotein D1 polypeptide, SMD1, Smn, snRNP D1, SNRPD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Snrpd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sm and related proteins
- ribonucleoprotein binding
- tail domain
- protein binding
- glycine arginine rich domain
- RNA binding
Pathways
Biological processes and signaling networks where the Snrpd1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- non-small cell lung cancer
- breast cancer
- preeclampsia
role in cell
- quantity
- apoptosis
- migration
- cell death
- replication in
- cell viability
- doxorubicin resistance
- splicing by
- S phase
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- catalytic step 2 spliceosome
- Cytoplasm
- cytosol
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Snrpd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- spliceosomal complex assembly
- spliceosomal snRNP assembly
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- U5 snRNP
- spliceosomal complex
- U2-type spliceosomal complex
- U2 snRNP
- U1 snRNP
- U4 snRNP
- nucleoplasm
- commitment complex
- U12-type spliceosomal complex
- nucleus
- pICln-Sm protein complex
- catalytic step 2 spliceosome
- methylosome
- precatalytic spliceosome
- SMN-Sm protein complex
- U4/U6 x U5 tri-snRNP complex
- U2-type catalytic step 2 spliceosome
- cytosol
- U2-type precatalytic spliceosome
- small nuclear ribonucleoprotein complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding