Itga3 Gene Summary [Rat]
Enables several functions, including fibronectin binding activity; integrin binding activity; and laminin binding activity. Involved in several processes, including maternal process involved in female pregnancy; positive regulation of epithelial cell migration; and regulation of cell projection organization. Located in cell surface; growth cone filopodium; and perinuclear region of cytoplasm. Part of integrin alpha3-beta1 complex. Is active in glutamatergic synapse and postsynaptic membrane. Biomarker of glomerulonephritis and myocardial infarction. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa. Orthologous to human ITGA3 (integrin subunit alpha 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itga3 |
| Official Name | integrin subunit alpha 3 [Source:RGD Symbol;Acc:1310333] |
| Ensembl ID | ENSRNOG00000004276 |
| Bio databases IDs | |
| Aliases | integrin subunit alpha 3 |
| Synonyms | Alpha3 integrin, CD49C, FRP-2, Galactoprotein B3, GAP-B3, ILNEB, Integrin alpha3, integrin subunit alpha 3, integrin subunit α 3, Integrin α 3, Itga3 (predicted), JEB7, MSK18, VCA-2, VL3A, VLA3a, VLA-3 alpha chain, VLA-3 α chain |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Itga3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protease binding
- ectodomain
- protein domain specific binding
- protein binding
- fibronectin binding
- FG-GAP-like repeat
- Integrin alpha (beta-propellor repeats)
- binding protein
- Integrin alpha
- cytoplasmic domain
- laminin binding
- integrin binding
- intracellular domain
- collagen binding
- membrane-proximal domain
- FG-GAP repeat
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Itga3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Caveolar-mediated Endocytosis Signaling
- CDK5 Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- HGF Signaling
- Integrin Signaling
- Molecular Mechanisms of Cancer
- NF-κB Activation by Viruses
- PAK Signaling
- Paxillin Signaling
- Rac Signaling
- Reelin Signaling in Neurons
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Role of Tissue Factor in Cancer
- Sertoli Cell-Sertoli Cell Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- metastasis
- congenital interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa
- hypoplasia
- nephrosis
- uterine serous papillary cancer
- sepsis
- growth failure
- pancreatic adenocarcinoma
- pancreatic epithelial cancer
role in cell
- quantity
- expression in
- apoptosis
- activation
- formation
- activation in
- growth
- proliferation
- phosphorylation in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- actin-rich protrusion
- extracellular vesicles
- invadopodia
- cell surface
- cell borders
- cell periphery
- perinuclear region
- pericentriolar regions
- membrane surface
- cellular membrane
- focal adhesions
- cell cortex
- intercellular junctions
- membrane ruffles
- plasma membrane extracellular face
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- basolateral membrane
- cell membrane-lagging edges
- synaptic vesicles
- neuromuscular junctions
- growth cone
- neurites
- synaptosomes
- synapse
- lateral cell-cell contacts
- microsomal membrane
- membrane processes
- filopodia
- cell membrane leading edge
- perikaryon
- postsynaptic density
- excitatory synapses
- plasma
- basement membrane
- podocyte slit diaphragm
- glomerular basement membrane
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Itga3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- exploration behavior
- negative regulation of Rho protein signal transduction
- response to xenobiotic stimulus
- skin development
- memory
- heart development
- integrin-mediated signaling pathway
- neuron migration
- renal filtration
- nephron development
- positive regulation of cell-substrate adhesion
- positive regulation of neuron projection development
- positive regulation of epithelial cell migration
- lung development
- cell-matrix adhesion
- maternal process involved in female pregnancy
- Rho protein signal transduction
- dendritic spine maintenance
- cell adhesion mediated by integrin
- mesodermal cell differentiation
- positive regulation of gene expression
- response to gonadotropin stimulus
- leukocyte migration
- regulation of Wnt receptor signaling pathway
- regulation of transforming growth factor beta receptor signaling pathway
- regulation of BMP signaling pathway
- negative regulation of cell projection organization
Cellular Component
Where in the cell the gene product is active
- excitatory synapse
- external side of plasma membrane
- receptor complex
- synaptic membrane
- presynaptic active zone membrane
- integrin complex
- plasma membrane
- cell surface
- filopodium membrane
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- focal adhesion
- postsynaptic membrane
- neuromuscular junction
- basolateral plasma membrane
- cell periphery
- alpha3-beta1 integrin complex
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- collagen binding
- metal ion binding
- protein heterodimerization activity
- fibronectin binding
- integrin binding
- protease binding
- laminin binding