Aup1 Gene Summary [Rat]
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including lipid droplet formation; lipophagy; and protein localization to lipid droplet. Predicted to be located in autophagosome; endoplasmic reticulum; and lipid droplet. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human AUP1 (AUP1 lipid droplet regulating VLDL assembly factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aup1 |
| Official Name | AUP1, lipid droplet regulating VLDL assembly factor [Source:RGD Symbol;Acc:1591777] |
| Ensembl ID | ENSRNOG00000007842 |
| Bio databases IDs | |
| Aliases | AUP1, lipid droplet regulating VLDL assembly factor |
| Synonyms | AA589454, ancient ubiquitous protein 1, AUP1 lipid droplet regulating VLDL assembly factor, AUP1, lipid droplet regulating VLDL assembly factor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aup1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- UBE2G2 binding region
- ubiquitin protein ligase binding
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- acetyltransferase domain
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- Endoplasmic Reticulum
- lipid droplets
- endoplasmic reticulum membrane
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aup1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retrograde protein transport, ER to cytosol
- lipid particle organization
- response to virus
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- lipid particle
- extracellular vesicular exosome
- membrane
- cytoplasmic vesicle
- endoplasmic reticulum
- autophagic vacuole
Molecular Function
What the gene product does at the molecular level
- ubiquitin conjugating enzyme binding
- protein binding
- ubiquitin protein ligase binding
- ubiquitin binding