Aup1 Gene Summary [Mouse]
The protein encoded by this gene contains several conserved domains including a hydrophobic domain, an acetyltransferase domain, a ubiquitin binding domain, and a domain required for recruitment of ubiquitin-conjugating enzyme E2 G2 (Ube2g2). In humans, this protein localizes to the endoplasmic reticulum and to lipid droplets. This protein is thought to be involved both in the degradation of misfolded proteins from the endoplasmic reticulum and in the storage of neutral lipids. Reduced expression of the human ortholog of this gene strongly reduces lipid droplet clustering in the cell, and causes stabilization of misfolded proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Details
| Type | Protein Coding |
| Official Symbol | Aup1 |
| Official Name | ancient ubiquitous protein 1 [Source:MGI Symbol;Acc:MGI:107789] |
| Ensembl ID | ENSMUSG00000068328 |
| Bio databases IDs | |
| Aliases | ancient ubiquitous protein 1 |
| Synonyms | AA589454, ancient ubiquitous protein 1, AUP1 lipid droplet regulating VLDL assembly factor, AUP1, lipid droplet regulating VLDL assembly factor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aup1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- UBE2G2 binding region
- ubiquitin protein ligase binding
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- acetyltransferase domain
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- Endoplasmic Reticulum
- lipid droplets
- endoplasmic reticulum membrane
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aup1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retrograde protein transport, ER to cytosol
- lipid particle organization
- response to virus
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- lipid particle
- extracellular vesicular exosome
- membrane
- cytoplasmic vesicle
- endoplasmic reticulum
- autophagic vacuole
Molecular Function
What the gene product does at the molecular level
- ubiquitin conjugating enzyme binding
- protein binding
- ubiquitin protein ligase binding
- ubiquitin binding