Oprm1 Gene Summary [Rat]
Enables several functions, including G-protein beta-subunit binding activity; morphine receptor activity; and voltage-gated calcium channel activity. Involved in several processes, including G protein-coupled receptor signaling pathway; estrous cycle; and regulation of signal transduction. Located in several cellular components, including dendrite; focal adhesion; and perikaryon. Is active in postsynaptic membrane; presynaptic membrane; and spine apparatus. Used to study obesity. Biomarker of brain ischemia; extrahepatic cholestasis; human immunodeficiency virus infectious disease; obesity; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; drug dependence (multiple); drug psychosis; and withdrawal disorder (multiple). Orthologous to human OPRM1 (opioid receptor mu 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Oprm1 |
| Official Name | opioid receptor, mu 1 [Source:RGD Symbol;Acc:3234] |
| Ensembl ID | ENSRNOG00000018191 |
| Bio databases IDs | |
| Aliases | opioid receptor, mu 1 |
| Synonyms | LMOR, MOP, MOP-R, MOR, M-OR-1, MOR-1O, MORA, MU OPIOID receptor, Mu OR, OPIATE receptor MU, opioid receptor mu 1, opioid receptor, mu 1, OPRM, Oprrm1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Oprm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- beta-endorphin receptor
- opioid receptor
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- DRY motif
- protein domain specific binding
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- voltage-gated calcium channel
- NPXY motif
- ligand-induced binding site
- cytoplasmic domain
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the Oprm1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- HIV infection
- infection
- hepatitis C
- irritable bowel syndrome
- chronic hepatitis C
- diarrhea
- rheumatoid arthritis
- non-insulin-dependent diabetes mellitus
- lymphoma
regulated by
- naltrindole
- 14-methoxymetopon
- morphine
- buprenorphine
- levorphanol
- 7-benzylidenenaltrexone
- estrogen
- [D-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin
- delta-9-tetrahydrocannabinol
- T lymphocytes
role in cell
- function
- expression in
- production in
- phosphorylation in
- proliferation
- apoptosis
- quantity
- activation in
- binding in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- organelle
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- focal adhesions
- filamentous network
- Nucleus
- endosomes
- sarcoplasmic reticulum
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- presynaptic membrane
- postsynaptic membrane
- dendritic spines
- nerve ending
- synapse
- sarcolemma
- melanosomes
- transverse tubules
- membrane rafts
- perikaryon
- axons
- dendrites
- axon terminals
- presynaptic terminals
- dendritic shafts
- premelanosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Oprm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- opioid receptor signaling pathway
- adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- negative regulation of cell proliferation
- regulation of cellular response to stress
- behavioral response to ethanol
- phospholipase C-activating G-protein coupled receptor signaling pathway
- negative regulation of Wnt protein secretion
- sensory perception
- neuropeptide signaling pathway
- positive regulation of ERK1 and ERK2 cascade
- calcium ion transmembrane transport
- cellular response to morphine
- regulation of N-methyl-D-aspartate selective glutamate receptor activity
- sensory perception of pain
- positive regulation of neurogenesis
Cellular Component
Where in the cell the gene product is active
- dendrite
- endosome
- endoplasmic reticulum
- Golgi apparatus
- synapse
- perikaryon
- neuron projection
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- morphine receptor activity
- G-protein coupled receptor activity
- neuropeptide binding
- protein binding
- beta-endorphin receptor activity
- G-protein alpha-subunit binding
- G-protein beta-subunit binding
- voltage-gated calcium channel activity