Pdhb Gene Summary [Rat]
Enables pyruvate dehydrogenase (acetyl-transferring) activity. Involved in pyruvate decarboxylation to acetyl-CoA. Part of pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHB (pyruvate dehydrogenase E1 subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdhb |
| Official Name | pyruvate dehydrogenase E1 beta subunit [Source:RGD Symbol;Acc:1359146] |
| Ensembl ID | ENSRNOG00000007895 |
| Bio databases IDs | |
| Aliases | pyruvate dehydrogenase E1 beta subunit |
| Synonyms | 2610103L06Rik, E1beta, Odpb, PDHB1, PDHBD, PDHE1-B, PHE1B, Pyruvate dehydrogenase, Pyruvate dehydrogenase-beta, pyruvate dehydrogenase E1 subunit beta, pyruvate dehydrogenase E1 subunit β, Pyruvate dehydrogenase (lipoamide), pyruvate dehydrogenase (lipoamide) beta, pyruvate dehydrogenase (lipoamide) β, Pyruvate dehydrogenase-β |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pdhb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transketolase, pyrimidine binding domain
- enzyme
- protein binding
- pyruvate dehydrogenase (lipoamide)
- Transketolase, C-terminal domain
- thiamine pyrophosphate-dependent enzyme pyrimidine binding domain
- aldehyde or oxo group:NAD or NADP oxidoreductase
- pyruvate dehydrogenase
Pathways
Biological processes and signaling networks where the Pdhb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- deficiency of pyruvate dehydrogenase e1-beta
- microvesicular hepatic steatosis
- Alzheimer disease
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- Leigh syndrome
regulated by
- D-glucose
- PKM
- insulin
- dexamethasone
- metribolone
- poly rI:rC-RNA
- streptozocin
- GABA
- Immunoglobulin
- AMPK
regulates
- acetyl-coenzyme A
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- mitochondrial matrix
- nucleoplasm
- photoreceptor inner segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pdhb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acetyl-CoA biosynthetic process from pyruvate
- tricarboxylic acid cycle
- glucose metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- pyruvate dehydrogenase complex
- mitochondrial matrix
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- pyruvate dehydrogenase (acetyl-transferring) activity
- pyruvate dehydrogenase (NAD+) activity