Ect2 Gene Summary [Rat]
Predicted to enable GTPase regulator activity; protein homodimerization activity; and small GTPase binding activity. Predicted to be involved in several processes, including activation of GTPase activity; bicellular tight junction assembly; and regulation of cell cycle process. Predicted to act upstream of or within cell morphogenesis. Predicted to be located in several cellular components, including bicellular tight junction; cleavage furrow; and midbody. Predicted to be part of centralspindlin complex. Predicted to be active in cell cortex and nucleus. Orthologous to human ECT2 (epithelial cell transforming 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ect2 |
| Official Name | epithelial cell transforming 2 [Source:RGD Symbol;Acc:1308524] |
| Ensembl ID | ENSRNOG00000024365 |
| Bio databases IDs | |
| Aliases | epithelial cell transforming 2 |
| Synonyms | ARHGEF31, ect2 oncogene, epithelial cell transforming 2, FLJ10461 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ect2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BRCT
- catalytic domain
- twin BRCT domain
- nuclear localization sequence
- enzyme binding
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- RhoGEF domain
- RhoGEF
- guanyl-nucleotide exchange factor
- BRCA1 C Terminus (BRCT) domain
- protein homodimerization
- Dbl homology domain
- breast cancer carboxy-terminal domain
Pathways
Biological processes and signaling networks where the Ect2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- lung squamous cell carcinoma
- lung cancer
- glioma formation
- squamous cell lung cancer
- non-small cell lung carcinoma
- lung adenocarcinoma
role in cell
- activation in
- apoptosis
- proliferation
- survival
- migration
- growth
- differentiation
- assembly
- attachment
- binucleation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- midbody
- intercellular junctions
- cytosol
- nucleoplasm
- nuclear bodies
- tight junctions
- cleavage furrow
- cellular protrusions
- central spindle
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ect2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein import into nucleus
- regulation of protein kinase activity
- cell morphogenesis
- protein transport
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- nervous system development
- protein homooligomerization
- positive regulation of neuron differentiation
- positive regulation of GTPase activity
- cellular response to calcium ion
- regulation of small GTPase mediated signal transduction
- cytokinesis after mitosis
- positive regulation of apoptotic process
- tight junction assembly
- cell differentiation
- cellular response to ionizing radiation
- activation of protein kinase activity
- regulation of cytokinesis, actomyosin contractile ring assembly
- cellular response to hydrogen peroxide
- regulation of attachment of spindle microtubules to kinetochore
- intracellular signal transduction
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cleavage furrow
- nucleoplasm
- nucleus
- tight junction
- centrosome
- cell-cell junction
- mitotic spindle
- cytoplasm
- cell cortex
- centralspindlin complex
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- GTPase activator activity
- guanyl-nucleotide exchange factor activity
- small GTPase binding